Polymorphisms in the glucocorticoid receptor gene and in the glucocorticoid-induced transcript 1 gene are associated with disease activity and response to glucocorticoid bridging therapy in rheumatoid arthritis.

Rheumatology International
Rogier A M QuaxRichard A Feelders

Abstract

Glucocorticoids (GC) are widely used in rheumatoid arthritis (RA). Ongoing active disease due to GC resistance may unfavorably influence long-term disease outcome in RA. We studied the association between the presence of glucocorticoid receptor (GR) and glucocorticoid-induced transcript 1 (GLCCI1) gene polymorphisms, which modulate GC sensitivity, and baseline disease activity score (DAS) and efficacy of GC bridging therapy in RA. We prospectively studied in vivo GC sensitivity in 138 patients with recent-onset or longstanding RA. In vivo GC sensitivity was expressed as the relative decrease in DAS following 2 weeks of standardized GC therapy. All patients were genotyped for the GR polymorphisms BclI (rs41423247), N363S (rs6195), 9β (rs6198), ER22/23EK (rs6189 + rs6190), and the GLCCI1 variant rs37972 and subsequently divided in groups carrying a polymorphism associated with increased GC sensitivity (BclI-G allele, N363S-G allele, GLCCI1-C allele) or decreased GC sensitivity (9β-G allele, ER22/23EK-A/A allele, GLCCI1-T allele). Differences in baseline DAS and relative decrease in DAS in the different genotype groups were analyzed using analysis of covariance and linear regression. Baseline DAS was higher in patients who carried...Continue Reading

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Citations

May 18, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y XieH J Kaminski
May 18, 2016·Stress : the International Journal on the Biology of Stress·Natalie A HadadLori A Knackstedt
Feb 9, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Natalie Z CvijanovichHector R Wong
May 11, 2017·The Clinical Respiratory Journal·Shinji ChibaKohei Yamauchi
Jul 27, 2017·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Xiao-Hong LiuYao-Guang Zhang
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Jul 20, 2020·The Pharmacogenomics Journal·Arno C HesselsCoen A Stegeman
Jul 16, 2020·International Journal of Molecular Sciences·Dmitry S MikhaylenkoAndrey A Zamyatnin
Apr 1, 2021·Journal of Translational Medicine·Katarzyna ZaorskaMichał Nowicki
Apr 18, 2021·Molecular and Cellular Endocrinology·Clarissa Silva Martins, Margaret de Castro
Jul 19, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Roza MotavalliJalal Etemadi

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Methods Mentioned

BETA
ESR
genotyping

Software Mentioned

GraphPad Prism
FLARE
SPSS

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