Polymorphisms in the glutamate decarboxylase 1 gene associated with heroin dependence

Biochemical and Biophysical Research Communications
W WuS B Li

Abstract

The GAD1 gene encodes the 67-kDa glutamic acid decarboxylase isoform (GAD67), the rate-limiting enzyme responsible for γ-aminobutyric acid (GABA) biosynthesis from glutamic acid, and may be involved in the development of drug dependence. To identify markers contributing to the genetic susceptibility to heroin dependence, this study examined the potential association between heroin dependence and 15 single nucleotide polymorphisms (SNPs, rs1978340, rs3762556, rs3791878, rs3749034, rs11542313, rs2241165, rs2241164, rs769407, rs3749033, rs16858977, rs701492, rs16858988, rs4668331, rs7578661, rs769395) of GAD1 gene using the MassARRAY system. Participants included 370 heroin-dependent subjects and 389 healthy controls. The allelic or genotypic frequencies of the rs1978340 (promoter region), rs3791878 (promoter region), and rs11542313 (exon 3) polymorphisms in heroin addicts were significantly different from those in healthy controls. Strong linkage disequilibrium was observed in two blocks (D'>0.9). Significantly more C-C-C-C-A haplotypes (p=0.0053 after Bonferroni correction) and significantly fewer T-C-A-C-A haplotypes (p=0.0003 after Bonferroni correction) were found in heroin dependent subjects. These findings point to a role f...Continue Reading

References

Dec 5, 1998·Drug and Alcohol Dependence·M B van den BreeR W Pickens
Jan 1, 1999·Trends in Pharmacological Sciences·J J Soghomonian, D L Martin
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·S F KashS Baekkeskov
Jan 23, 2002·Molecular Psychiatry·M MallatV Moura Neto
Jul 6, 2004·The European Journal of Neuroscience·Stéphanie Caillé, Loren H Parsons
Nov 16, 2004·Annals of the New York Academy of Sciences·George R Uhl
Apr 5, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·M D LundorfO Mors
Oct 28, 2006·Alcoholism, Clinical and Experimental Research·El-Wui LohAndrew T A Cheng
Mar 4, 2008·The European Journal of Neuroscience·Anna R CartaGaetano Di Chiara
Oct 11, 2008·PLoS Genetics·Jean-Baptiste VeyrierasJonathan K Pritchard
Oct 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·R SattaA Guidotti
Jun 9, 2009·Genes, Brain, and Behavior·O LevranM J Kreek
Apr 2, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefano MarencoDaniel R Weinberger
Feb 9, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Shun-Chiao ChangSusan L Santangelo

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Citations

Dec 18, 2013·Journal of Molecular Neuroscience : MN·Yunpeng WangJianghua Lai
Sep 12, 2014·Current Psychiatry Reports·Brian ReedMary Jeanne Kreek
Mar 12, 2013·Biochemical and Biophysical Research Communications·X D MaB L Chen
Aug 19, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Orna LevranMary Jeanne Kreek
Jul 16, 2014·PloS One·Chia-Hsiang ChenDing-Lieh Liao
Dec 15, 2016·Pharmacogenomics·Siriluk VeerasakulSutisa Nudmamud-Thanoi

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