Polymorphisms in the hMSH2 gene and the risk of primary lung cancer

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Chi Young JungJae Yong Park

Abstract

Polymorphisms in the DNA repair genes may be associated with differences in the capacity to repair DNA damage, and so this can influence an individual's susceptibility to lung cancer. To test this hypothesis, we investigated the association of hMSH2 -118T>C, IVS1+9G>C, IVS10+12A>G, and IVS12-6T>C genotypes and their haplotypes with the risk of lung cancer in a Korean population. The hMSH2 genotypes were determined in 432 lung cancer patients and in 432 healthy controls who were frequency matched for age and gender. The hMSH2 haplotypes were estimated based on a Bayesian algorithm using the Phase program. The presence of at least one IVS10+12G allele was associated with a significantly decreased risk of adenocarcinoma, as compared with the IVS10+12AA genotype [adjusted odds ratio (OR), 0.59; 95% confidence interval (95% CI), 0.40-0.88; P = 0.01], and the presence of at least one IVS12-6C allele was associated with a significantly increased risk of adenocarcinoma, as compared with the IVS12-6TT genotype (adjusted OR, 1.52; 95% CI, 1.02-2.27; P = 0.04). Consistent with the results of the genotyping analysis, the TGGT haplotype with no risk allele was associated with a significantly decreased risk of adenocarcinoma, as compared wit...Continue Reading

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Dec 7, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sukki ChoJae Yong Park
Nov 8, 2011·Clinics in Chest Medicine·Charles S Dela CruzRichard A Matthay
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Aug 7, 2020·International Journal of Molecular Sciences·Fabian CajaPavel Vodicka
Nov 28, 2021·Biotechnology and Applied Biochemistry·Sidhartha SinghManoj Baranwal

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