Polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin genes that correlate with human diseases in a North Indian population.

Molecular Biology Reports
Ranbir C SobtiSharwan K Singh

Abstract

Two genes HPC/ELAC-2 and AAT were studied in north Indian population. HPC/ELAC-2 was studied in prostate cancer cases and AAT was studied in COPD patients. HPC/ELAC-2 is considered as an important cancer-susceptibility gene in prostate cancer. There are two common polymorphisms of this gene, i.e., Ser217Leu and Ala541Thr. Alpha 1 antitrypsin is a highly polymorphic anti-elastase enzyme, especially active in the protection of alveoli and liver. In the present study, we observed the distribution of two deficient alleles PiZ and Pi S in COPD patients. We extracted the DNA from 157 prostate cancer cases, 200 COPD patients, 170 BPH and 370 healthy controls. The polymorphisms were studied by PCR-RFLP technique. The mutant genotype (Leu/Leu) of HPC/ELAC-2 was present in 9.6, 7.6 and 5.9% of BPH, cancer cases and healthy controls, respectively. Higher risk of Ser/Leu as well as Leu/Leu had shown when compared to healthy controls. That was about 1.5 and 1.7-fold (OR = 1.55; 95% CI = 0.96-2.51; OR = 1.70; 95% CI = 0.74-3.92), respectively. Risk was found to be increased in smokers and those consuming non-vegetarian diet. Our results suggest that the HPC/ELAC-2 polymorphisms, especially in localized cases, could help to predict prostate c...Continue Reading

References

Sep 1, 1977·The American Journal of Medicine·F KueppersK Offord
Nov 26, 1976·Biochimica Et Biophysica Acta·M C OwenS O Brennan
Jan 1, 1990·Journal of Clinical Epidemiology·B A RybickiB H Cohen
Dec 1, 1989·Trends in Genetics : TIG·R G Crystal
Jun 24, 1988·The American Journal of Medicine·M BrantlyR G Crystal
Mar 1, 1986·Chest·J LiebermanA Sastre
May 1, 1970·Annals of Internal Medicine·R K LarsonH H Fudenberg
Dec 1, 1994·The European Respiratory Journal·E TarjánL Vaszár
Oct 6, 1993·Journal of the National Cancer Institute·K J Pienta, P S Esper
Dec 1, 1996·Chest·R W CarrellR Foreman
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·E K SilvermanF E Speizer
Jan 28, 1999·American Journal of Respiratory Cell and Molecular Biology·A J SandfordP D Paré
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·N SeersholmA Dirksen
Feb 15, 2001·Nature Genetics·S V TavtigianL A Cannon-Albright
Mar 20, 2001·American Journal of Human Genetics·D VespriniS A Narod
Oct 10, 2002·British Journal of Cancer·J C MeitzUNKNOWN Cancer Research UK/BPG UK Familial Prostate Cancer Study Collaborators
Sep 2, 2003·International Journal of Cancer. Journal International Du Cancer·Hiroyuki TakahashiHiroshi Hano
Dec 25, 1964·Science·F KUEPPERSA G BEARN

❮ Previous
Next ❯

Citations

Apr 11, 2014·Iranian Red Crescent Medical Journal·Bita GeramizadehMohammad-Ali Ghayoumi
Nov 2, 2017·Multidisciplinary Respiratory Medicine·Ardak ZhumagaliyevaIlaria Ferrarotti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.