Abstract
Anti-tumor necrosis factor-α (TNF-α) is used for the treatment of severe cases of IBD, including Crohn's disease (CD) and ulcerative colitis (UC). However, one-third of the patients do not respond to the treatment. We have previously investigated whether single nucleotide polymorphisms (SNPs) in genes involved in inflammation were associated with response to anti-TNF therapy among patients with CD or UC. A new cohort of patients was established for replication of the previous findings and to identify new SNPs associated with anti-TNF response. Fifty-three SNPs assessed previously in cohort 1 (482 CD and 256 UC patients) were genotyped in cohort 2 (587 CD and 458 UC patients). The results were analysed using logistic regression (adjusted for age and gender). Ten SNPs were associated with anti-TNF response either among patients with CD (TNFRSF1A(rs4149570) (OR: 1.92, 95% CI: 1.02-3.60, P = 0.04), IL18(rs187238) (OR: 1.35, 95% CI: 1.00-1.82, P = 0.05), and JAK2(rs12343867) (OR: 1.35, 95% CI: 1.02-1.78, P = 0.03)), UC (TLR2(rs11938228) (OR: 0.55, 95% CI: 0.33-0.92, P = 0.02), TLR4(rs5030728) (OR: 2.23, 95% CI: 1.24-4.01, P = 0.01) and (rs1554973) (OR: 0.49, 95% CI: 0.27-0.90, P = 0.02), NFKBIA(rs696) (OR: 1.45, 95% CI: 1.06-2.00, P...Continue Reading
References
Jan 1, 1995·Cytokine·S A SiegelP E Daddona
Apr 1, 1995·Cytokine·B J ScallonJ Ghrayeb
Nov 1, 1993·Molecular Immunology·D M KnightP Daddona
Jan 11, 2001·The American Journal of Gastroenterology·R D CohenS B Hanauer
Jan 15, 2002·Gut·T ten HoveS J H van Deventer
Jun 7, 2002·The Pharmacogenomics Journal·S MascherettiS Schreiber
Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
Oct 4, 2003·Journal of Leukocyte Biology·Kate SchroderDavid A Hume
May 13, 2004·Gut·T LjungR Löfberg
Dec 13, 2005·The New England Journal of Medicine·Paul RutgeertsJean Frédéric Colombel
Feb 17, 2006·European Journal of Immunology·Marieke A HoeveFrank A W Verreck
Apr 20, 2007·Genes and Immunity·S RafiqT M Frayling
Sep 6, 2007·Annals of the New York Academy of Sciences·Hyun-Dong Chang, Andreas Radbruch
Mar 22, 2008·Clinical Chemistry·Andrew J P SmithSteve E Humphries
Jun 7, 2008·Cellular and Molecular Life Sciences : CMLS·L VerstrepenR Beyaert
Oct 14, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sarah CaspersenUNKNOWN Danish Crohn Colitis Database
Aug 18, 2009·The Journal of Rheumatology·Der-Yuan ChenJoung-Liang Lan
Sep 22, 2009·The Journal of Allergy and Clinical Immunology·Yuki HitomiMayumi Tamari
Dec 3, 2010·Journal of Crohn's & Colitis·A DignassUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jan 21, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Enitan D CarrolWilliam E Ollier
Feb 15, 2011·Human Immunology·Guo-Bing WangShi-Lei Jia
Jul 9, 2011·PloS One·Shunxin SongJianping Wang
Sep 21, 2011·PloS One·Andreas GastRajiv Kumar
Nov 29, 2011·Pigment Cell & Melanoma Research·Andrea D'Osualdo, John C Reed
Jan 20, 2012·Nature·Till StrowigRichard Flavell
Aug 28, 2012·Postȩpy higieny i medycyny doświadczalnej·Violetta DziedziejkoAndrzej Pawlik
Sep 11, 2012·European Journal of Clinical Pharmacology·Diana Lacruz-GuzmánPablo Conesa-Zamora
Oct 9, 2012·Journal of Crohn's & Colitis·Axel DignassGert Van Assche
Nov 29, 2012·Journal of Applied Genetics·Vesna SpasovskiSonja Pavlovic
Feb 14, 2013·Gene·Praveen Kumar JaiswalRama Devi Mittal
Apr 12, 2013·Genetic Testing and Molecular Biomarkers·Steffen BankPaal Skytt Andersen
May 7, 2013·Cell Death and Differentiation·V SagulenkoK J Stacey
Apr 30, 2014·The Pharmacogenomics Journal·S BankV Andersen
Jun 27, 2014·PloS One·Jacob SodeVibeke Andersen
Jun 28, 2014·PloS One·Steffen BankVibeke Andersen
Apr 10, 2015·Journal of the National Cancer Institute·Nasim MavaddatMontserrat Garcia-Closas
Oct 7, 2015·PloS One·Jacob SodeVibeke Andersen
Dec 25, 2015·PloS One·Steffen BankVibeke Andersen
Jul 16, 2016·Alimentary Pharmacology & Therapeutics·S BekV Andersen
Oct 5, 2016·The Pharmacogenomics Journal·J SodeV Andersen
Feb 1, 2017·The Pharmacogenomics Journal·S BankV Andersen
Jun 14, 2017·The Pharmacogenomics Journal·S BekV Andersen
Jul 12, 2017·The Pharmacogenomics Journal·N D LoftV Andersen
Feb 2, 2018·PloS One·Nikolai Dyrberg LoftVibeke Andersen
Citations
Mar 25, 2020·Current Opinion in Pulmonary Medicine·Heleen CrommelinColine H M van Moorsel
Jun 20, 2020·Scientific Reports·Yaping LiMing Chen
May 28, 2019·International Journal of Molecular Sciences·Martine A AardoomLissy de Ridder
Mar 11, 2020·Scientific Reports·Jose Manuel Sánchez-MaldonadoJuan Sainz
Sep 29, 2020·Frontiers in Medicine·Raja AtreyaBritta Siegmund
Sep 15, 2020·Frontiers in Pharmacology·Michal WalczakMarzena Skrzypczak-Zielinska
Jun 2, 2020·British Journal of Clinical Pharmacology·Sara Salvador-MartínLuis Andrés López-Fernández
Jan 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Panpan HouDeyin Guo
Nov 27, 2020·Frontiers in Pharmacology·Wenwen DingRonghui Du
Feb 25, 2021·Expert Review of Clinical Immunology·Ikram MezghicheElisabetta Bianchi
Feb 26, 2021·Frontiers in Pharmacology·Antonello Di Paolo, Giacomo Luci
Nov 18, 2020·Journal of Crohn's & Colitis·R KallaJ Satsangi
Mar 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vishal Khatri, Ramaswamy Kalyanasundaram
Apr 4, 2021·International Journal of Molecular Sciences·Dinh Nam TranEui-Bae Jeung
Apr 17, 2021·EBioMedicine·Guanglin CuiJon Florholmen
Apr 24, 2021·Pharmacogenomics·Charalabos AntonatosYiannis Vasilopoulos
Oct 15, 2020·Carbohydrate Polymers·Pan LiBing Du
Aug 19, 2021·Biomedical Reports·Kornyok KamdeeWarangkana Chunglok