Polymorphisms in the organic cation transporter genes SLC22A4 and SLC22A5 and Crohn's disease in a New Zealand Caucasian cohort

Immunology and Cell Biology
Euphemia LeungGeoffrey W Krissansen

Abstract

Polymorphisms in the organic cation transporter (OCTN) genes SLC22A4 (OCTN1; polymorphism 1672C/T) and SLC22A5 (OCTN2; polymorphism -207G/C) at the inflammatory bowel disease (IBD) 5 locus comprise a two-allele haplotype (SLC22A-TC) associated with increased risk for Crohn's disease (CD). In this study, we examined the contribution of the disease susceptibility haplotype SLC22A-TC to CD in a New Zealand Caucasian population. The frequencies of the gene polymorphisms 1672C/T and -207G/C were examined in 182 patients with CD and 188 ethnically matched controls by PCR-RFLP analysis. There was a significant difference in the allele frequency (0.444 vs 0.519; P = 0.041) of the 1672T polymorphism in the SLC22A4 gene between controls and patients with CD. In contrast, there was no significant difference (0.497 vs 0.552; P = 0.135) for the -207C polymorphism in the SLC22A5 gene. The homozygote SLC22A-TC diplotype was significantly associated with an increased risk for CD (odds ratio 2.19), and the SLC22A-TC haplotype was associated with increased risk (P = 0.0007) of ileocolonic involvement. The population-attributable risk for the SLC22A-TC haplotype is 15.1%. Thus, SLC22A-TC is associated with an increased risk of CD and disease phen...Continue Reading

References

Apr 25, 2000·American Journal of Human Genetics·J D RiouxK A Siminovitch
Dec 5, 2003·Current Biology : CB·Greg Gibson
Apr 27, 2004·Nature Genetics·Vanya D PeltekovaKatherine A Siminovitch
Oct 27, 2004·Journal of Human Genetics·Keiko YamazakiYusuke Nakamura
Sep 22, 2005·Immunology and Cell Biology·Euphemia LeungGeoffrey W Krissansen

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Citations

Jun 28, 2011·International Journal of Colorectal Disease·Chao XuanRui-Juan Tian
Dec 3, 2010·Journal of Crohn's & Colitis·Zhenwu LinWalter A Koltun
Jun 27, 2007·Journal of Gastroenterology and Hepatology·Jiwon HongGeoffrey W Krissansen
Jan 28, 2010·Pharmacological Reviews·Curtis D Klaassen, Lauren M Aleksunes
Sep 13, 2006·Gut·M C ArrietaJ B Meddings
Sep 15, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sonne R SrinivasPrem S Shekhawat
Aug 30, 2008·World Journal of Gastroenterology : WJG·Mei LiPin-Jin Hu
Apr 28, 2016·International Journal of Epidemiology·Liam G Fearnley, Michael Inouye
Oct 18, 2011·Biochimica Et Biophysica Acta·Irwin K Cheah, Barry Halliwell
Jan 10, 2017·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Eun Suk JungJae Hee Cheon
Apr 5, 2017·Journal of Cardiovascular Pharmacology·Luigi ServilloMaria Luisa Balestrieri
Apr 24, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyo Jin Park, Ji Ha Choi
Mar 3, 2007·Clinical Pharmacology and Therapeutics·C N A PalmerS Mukhopadhyay
Mar 27, 2015·Journal of Gastroenterology·Donal SheehanFergus Shanahan
Feb 14, 2020·Nutrition Research Reviews·Irina BorodinaDouglas B Kell
Dec 20, 2019·Pharmacological Reviews·Hermann Koepsell
Oct 23, 2020·Metabolites·Hauke J Weiss, Stefano Angiari
Jan 30, 2020·Acta Pharmaceutica Sinica. B·Wenxin SongLigong Chen

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