PMID: 9434876Jan 22, 1998Paper

Polymorphisms in the p53 gene in thyroid tumours and blood samples of children from areas in Belarus

Mutation Research
S HillebrandtC Reiners

Abstract

We present changes in the p53 gene in a group of 70 thyroid tumours and 40 blood samples obtained from children from Belarus. Three thyroid tumours show a polymorphism in exon 6 (codon 213) and 5 tumours show a polymorphism in intron 6, 37 bp upstream to the 5'-end of exon 7. Only one patient has a mutation in exon 7 (codon 258) resulting in an amino acid substitution in the protein p53. The distribution of polymorphisms in the 40 blood samples was as follows: three patients had a polymorphism in exon 6 and two persons had a polymorphism in intron 6. One polymorphism in intron 6 was also found in the group of 30 healthy children from Belarus. The fact that the differences in the sequence in p53 found in the tumours was also seen in the blood of these patients demonstrates that they are polymorphisms not induced by radiation exposure. It is difficult to conclude, if the polymorphisms found by us could be associated with the predisposition to radiation-induced cancer.

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Citations

Jun 18, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·José Luis Soto MartínezMiguel Angel López-Nevot
Feb 26, 2000·Thyroid : Official Journal of the American Thyroid Association·A V PisarchikJ Figge
Jan 1, 2004·Hereditary Cancer in Clinical Practice·Xuan LiuUte Hamann
Dec 12, 2012·Journal of Natural Science, Biology, and Medicine·K SailajaS Vishnupriya
Jun 2, 2012·North American Journal of Medical Sciences·B LajinSakur A Alhaj
Apr 22, 2009·Journal of Cellular and Molecular Medicine·Roman HrstkaBorivoj Vojtesek
Apr 29, 2000·Seminars in Nuclear Medicine·R M Tuttle, D V Becker
Mar 22, 2006·Oncogene·E C PietschM E Murphy
Aug 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Sarika SharmaArun Gupta
Jan 26, 2000·British Journal of Cancer·M SantoroE D Williams

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