Polymorphisms in the promoter and coding regions of the synapsin III gene. A lack of association with schizophrenia

Neuropsychobiology
K ImaiT Suzuki

Abstract

The human synapsin III gene, located on chromosome 22q12-13, has previously been reported to indicate a susceptibility for schizophrenia. Noval rare variants (Thr136Thr in exon 3, Pro468Ser, Glu525Gln and Pro534Leu in exon 12, and 1769 G/C in the untranslated region of exon 13) were found in addition to the polymorphic variant (-196 G/A in the promoter region). No significant differences in genotypic or allelic frequencies of the -196 G/A polymorphism were found between 87 unrelated schizophrenic patients and 100 healthy controls, even when the patients were diagnostically subdivided into subtypes and course specifiers. Furthermore, allelic frequencies of the GATG repeat in intron 1 were not significantly different between the patients and the controls. These results suggest that synapsin III gene polymorphisms are not associated with schizophrenia.

Citations

Jun 19, 2013·DNA and Cell Biology·Ayşe Nur İnci KenarMehmet Emin Erdal
Mar 3, 2006·Neuropsychobiology·Herbert M LachmanTakuya Saito
Dec 24, 2008·BMC Medical Genetics·Brenda C MurphyShiva M Singh
May 19, 2005·Psychiatric Genetics·Herbert M LachmanTakuya Saito
Feb 13, 2002·American Journal of Medical Genetics·Ming-Ta TsaiChia-Hsiang Chen
Aug 11, 2011·Seminars in Cell & Developmental Biology·Barbara PortonHung-Teh Kao
Sep 22, 2009·Neuroscience Letters·Qi ChenXiangning Chen
May 21, 2011·Trends in Neurosciences·Clarissa L Waites, Craig C Garner
Aug 19, 2021·Neuroscience and Biobehavioral Reviews·Francesca LonghenaArianna Bellucci

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