PMID: 8995185Jan 1, 1997Paper

Polymorphisms in the TNF gene cluster and MHC serotypes in the West of Scotland

Immunogenetics
G GallagherM Field

Abstract

We examined the distribution of polymorphic elements within the tumor necrosis factor (TNF) gene cluster in 105 unrelated individuals and determined their relationship to class I and class II major histocompatibility complex (MHC) antigens, and to the highly polymorphic microsatellites TNFa and TNFb. The data demonstrate the contribution of elements within the TNF cluster to two extended haplotypes which are recognized to straddle the MHC. The A1.B8.DR3 haplotype appears to contain the TNF alleles TNFa2, TNFb3, LT.Nco-1.B*1, and TNF-308.2, while the A3.B7.DR2 haplotype is associated with the TNF alleles TNFa11, TNFb6, TNFc1, LT.Nco-1.B*2, LT.AspH1.1, TNF-308.1, and TNFe1. The presence of other extended associations which covered smaller parts of the MHC was also suggested. In most cases, the associations described here were in keeping with previously described extended haplotypes which dominate the structure of the MHC, but these did not always match completely. Taken together, these data suggest that the structure of the TNF locus is well integrated into the rest of the MHC but that important ethnic differences may exist.

Citations

Mar 24, 1999·Cancer Genetics and Cytogenetics·S FrigerioA Boiardi
Apr 2, 2002·Human Immunology·Bao-Ying FeiA Salvador Peña
Aug 12, 1999·FEMS Immunology and Medical Microbiology·M W Raza, C C Blackwell
Oct 23, 1997·Tissue Antigens·M FieldC Campbell
Nov 5, 1998·Tissue Antigens·P FeichtlbauerE D Albert
Nov 20, 1998·Tissue Antigens·A Foissac, A Cambon-Thomsen
Feb 7, 2002·Annals of the Rheumatic Diseases·T HöhlerE Märker-Hermann
Jul 29, 2006·BMC Medical Genetics·Olga O FavorovaMichael F Ochs
Dec 3, 1999·British Journal of Haematology·J FitzgibbonR K Gupta
Jul 21, 2000·Tissue Antigens·A FoissacA Cambon-Thomsen
Mar 4, 2006·Expert Review of Molecular Diagnostics·Cara M MartinJohn J O'Leary
Oct 6, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chung-Ji LiuYann-Jinn Lee
Jun 18, 2016·Molecular Diagnosis & Therapy·Kapil BandilRavi Mehrotra
Aug 5, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Herlina Y HandokoBryan J Mowry
Mar 27, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·G A StanczukS Bergstrom
Sep 5, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Paulo CanedoJosé C Machado

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
E CiusaniM Sandberg-Wollheim
Proceedings of the National Academy of Sciences of the United States of America
C V JongeneelA Cambon-Thomsen
European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
G GrimsleyL J Abraham
© 2022 Meta ULC. All rights reserved