Polymorphisms in the Toll-like receptor 3 (TLR3) gene are associated with the natural course of hepatitis B virus infection in Caucasian population

Scientific Reports
Janett FischerFlorian van Bömmel

Abstract

Innate immunity can induce spontaneous hepatitis B surface antigen (HBsAg) seroclearance (SC) of hepatitis B virus (HBV) infection or transition towards an inactive carrier state. Toll-like receptor (TLR) 3 signalling has been linked to these processes. Alterations in the TLR3 gene might impair immune responses against HBV. In our study, we analysed the impact of the TLR3 polymorphisms rs3775291 and rs5743305 on the natural course of HBV infection. In this retrospective study, a Caucasian cohort of 621 patients with chronic HBV infection (CHB), 239 individuals with spontaneous HBsAg SC, and 254 healthy controls were enrolled. In the CHB group, 49% of patients were inactive carriers, and 17% were HBeAg-positive. The TLR3 rs3775291 A allele was associated with a reduced likelihood of spontaneous HBsAg SC and HBeAg SC, and an increased risk of developing chronic hepatitis B. In haplotype analysis, the haplotype including both risk variants rs3775291A and rs5743305A had the lowest likelihood of HBsAg SC. Further research in larger cohorts and functional analyses are needed to shed light on the impact of TLR3 signalling.

References

May 12, 2000·Immunological Reviews·P A Knolle, G Gerken
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kiminori KimuraFrancis V Chisari
Jun 5, 2003·European Journal of Immunology·Katrin SchwarzMartin F Bachmann
May 14, 2005·Journal of Virology·Masanori IsogawaFrancis V Chisari
Apr 17, 2007·The Journal of Biological Chemistry·C T Ranjith-KumarC Cheng Kao
Oct 12, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jun WuJoerg F Schlaak
Jan 19, 2008·Clinical Microbiology Reviews·Elisabeth VercammenRudi Beyaert
Mar 25, 2008·Advances in Genetics·Nianjun LiuHongyu Zhao
May 29, 2008·Annual Review of Genomics and Human Genetics·B S Weir
Oct 10, 2008·Journal of Virology·Mathis Heydtmann
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T Jake Liang
May 29, 2009·Journal of Medical Virology·Eva AskarSabine Mihm
Jun 30, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Peng ZhouXiao-Xin Li
Sep 7, 2011·Digestive Diseases·Tanja BauerUlrike Protzer
Jul 1, 2010·Viruses·Malika Ait-GoughoulteDavid Durantel
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Jul 25, 2012·Journal of Medical Virology·Ahmed Al-QahtaniFahad N Almajhdi
Feb 14, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guanggang Li, Zhendong Zheng
Feb 11, 2014·Virology Journal·Aurelia Busca, Ashok Kumar
May 7, 2014·Journal of Hepatology·Arjan BoltjesAndrea M Woltman
Aug 19, 2014·World Journal of Gastroenterology : WJG·Catherine M N Croagh, John S Lubel
Oct 12, 2014·Current Opinion in Infectious Diseases·Antonio Bertoletti, Laura Rivino
Oct 22, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masanori Isogawa, Yasuhito Tanaka
May 21, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Keyla Santos Guedes de SáAntonio Carlos Rosário Vallinoto
Jul 29, 2015·Journal of Hepatology·Souphalone LuangsayFabien Zoulim
Jun 18, 2016·Canadian Journal of Microbiology·Emine Firat GoktasAtilla Bozkurt
Dec 24, 2016·The International Journal of Biological Markers·Dongni ChenAihua Tan
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Jul 1, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaoming ChengT Jake Liang
Jul 14, 2017·Molecular Immunology·Reza NosratabadiMohammad Kazemi Arababadi
Feb 7, 2018·Gastroenterology·Aleksei SuslovMarkus H Heim

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Citations

Jun 25, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Hossein Mehrabi HabibabadiZohreh Sharifi
Feb 7, 2020·BMC Complementary Medicine and Therapies·Chao LuWei Hu
Feb 23, 2021·Frontiers in Immunology·Armando Andres Roca SuarezJoachim Lupberger
Apr 20, 2021·European Journal of Medical Genetics·Maria MonticelliGuglielmo Riccio
Aug 21, 2021·Journal of Zhejiang University. Science. B·Yujuan ChenHuashan Yi

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Methods Mentioned

BETA
biopsy

Software Mentioned

Haploview
DeFinetti
SPSS

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