Polymorphisms in the tumor necrosis factor (TNF) genes are associated with susceptibility to effects of ultraviolet-B radiation on induction of contact hypersensitivity

Tissue Antigens
H NiizekiJ W Streilein

Abstract

We investigated the allelic distributions of single nucleotide polymorphisms (SNPs) of the TNFA, TNFB and IKBL genes, 3 microsatellites within the tumor necrosis factor (TNF) region of HLA locus, and the HLA phenotypes as well as the TLR4 gene in Chromosome 9 in 26 healthy Caucasian volunteers. These individuals were also assessed as ultraviolet B (UVB)-susceptible (S) or UVB-resistant (R). Our results identified 12 UVB-S and 14 UVB-R individuals. Attempts to correlate particular HLA-A, -B, -C, and -DR antigens with the UVB phenotypes failed. Similarly, attempts to correlate SNP at the NcoI-RFLP within intron 1 of the TNFB, IKBL and TLR4 gene with UVB phenotypes also failed. However, microsatellite analyses of TNFa, TNFc, and TNFd markers revealed a significant increase in the frequencies of TNFa2 in UVB-S individuals (P=0.00032) and of TNFd3 in UVB-R individuals (P=0.012). Moreover, DNA sequencing analyses of 5 SNPs of the TNFA promoter region revealed a significant increase in the frequency of the allele B of the TNFA gene (TNFApB) representing the nucleotide A at position -863 and C at position -1031 (P=0.015). Since it is known that TNFa2 and TNFApB is a high TNF-alpha responder, whereas TNFd3 is a TNF-alpha low responder, ...Continue Reading

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Citations

Apr 1, 1994·Immunology Today·J W StreileinC Golomb
Mar 17, 2004·Toxicology and Applied Pharmacology·Diane E HeckJeffrey D Laskin
Dec 4, 2003·Biological Psychiatry·Ene-Choo TanRathi Mahendran
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Feb 3, 2006·The Keio Journal of Medicine·Thomas Schwarz
Oct 3, 2008·Journal of Dermatological Science·Shoko YokoiSachiko Miyagawa
Mar 14, 2007·Journal of Dermatological Science·Kazumoto KatagiriYutaka Hatano
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annemarie SleijffersHenk Van Loveren

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