Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.

Breast Cancer Research : BCR
Eric J JacobsEugenia E Calle

Abstract

Vascular endothelial growth factor (VEGF) plays a central role in promoting angiogenesis and is over-expressed in breast cancer. At least four polymorphisms in the VEGF gene have been associated with changes in VEGF expression levels: -2578C/A, -1154G/A and -634G/C are all located in the promoter region; and +936C/T is located in the 3'-untranslated region. We examined the association between these four VEGF polymorphisms and risk for breast cancer among postmenopausal women in CPS-II (Cancer Prevention Study II) Nutrition Cohort. This cohort was established in 1992 and participants were invited to provide a blood sample between 1998 and 2001. Included in this analysis were 501 postmenopausal women who provided a blood sample and were diagnosed with breast cancer between 1992 and 2001 (cases). Control individuals were 504 cancer-free postmenopausal women matched to the cases with respect to age, race/ethnicity, and date of blood collection (controls). We found no association between any of the polymorphisms examined and overall breast cancer risk. However, associations were markedly different in separate analyses of invasive cancer (n = 380) and in situ cancer (n = 107). The -2578C and -1154G alleles, which are both hypothesize...Continue Reading

References

Jan 15, 1997·Journal of the National Cancer Institute·G GaspariniT Tominaga
Mar 17, 2000·International Journal of Cancer. Journal International Du Cancer·B LinderholmR Henriksson
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Majid ShahbaziPaul N Harden
Nov 26, 2002·Bulletin of Experimental Biology and Medicine·N E Kushlinskii, E S Gershtein
Mar 29, 2003·Prostate Cancer and Prostatic Diseases·S BevanUNKNOWN CRC/BPG UK Familial Prostate Cancer Study Collaborators
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Peter KripplHellmut Samonigg
Sep 2, 2003·Cancer Causes & Control : CCC·Alpa V PatelMichael J Thun
Oct 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Xinnong Jiang, John R Couchman
Jul 22, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·K C SmithW M Howell
Aug 6, 2004·Endocrine Reviews·Napoleone Ferrara
Nov 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Michael I KoukourakisEfthimios Siviridis
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qianren JinAsta Försti
Feb 18, 2011·Cancer Causes & Control : CCC·Lauren R TerasHeather Spencer Feigelson

❮ Previous
Next ❯

Citations

Jul 4, 2008·Rheumatology International·Sergio Sánchez-EnríquezJosé Francisco Muñoz-Valle
Aug 3, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Kai HuDawei Zhang
Dec 2, 2010·Genetic Testing and Molecular Biomarkers·Gang BaoGaofeng Xu
Jul 25, 2008·Molecular Human Reproduction·Zhen Zhen ZhaoGrant W Montgomery
Feb 4, 2010·Pharmacogenetics and Genomics·Michael L MaitlandTeri E Klein
Dec 2, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alicia Beeghly-FadielWei Zheng
Oct 20, 2009·BMC Gastroenterology·Xiaoxiang GuanQingyi Wei
Dec 4, 2012·International Journal of Molecular Sciences·Doonyapat Sa-Nguanraksa, Pornchai O-Charoenrat
Jun 23, 2010·Clinical Medicine Insights. Oncology·Pankaj TanejaKazushi Inoue
Oct 21, 2009·Expert Opinion on Therapeutic Targets·Hailong Wu, Yin-Yuan Mo
Aug 1, 2014·International Journal of Molecular Sciences·Giorgia MarisiPaola Ulivi
Apr 14, 2010·Expert Opinion on Investigational Drugs·Raffaele LongoGiampietro Gasparini
Jan 7, 2015·Pharmacogenomics·David Della-MorteMario Roselli
May 20, 2016·Cancer Biology & Therapy·Hayra de Andrade Vieira-MonteiroRosane Vianna-Jorge
Feb 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rebecca Suk HeistDavid C Christiani
Jul 9, 2013·International Journal of Cancer. Journal International Du Cancer·Martha L SlatteryRoger K Wolff
Feb 13, 2009·Journal of Cellular and Molecular Medicine·Ian BuysschaertDiether Lambrechts
Jul 14, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Peer W KämmererJürgen Brieger
Jul 28, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Pervin VuralMüjdat Uysal
Sep 23, 2014·Archives of Gynecology and Obstetrics·Valeria C SandrimRicardo C Cavalli
Jan 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yulan YanXue Qin
May 6, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Christoph GrimmAlexander Reinthaller
Jun 15, 2007·Journal of Cancer Research and Clinical Oncology·C YapijakisE Patsouris
Sep 25, 2007·Breast Cancer Research and Treatment·Bryan P SchneiderDavid A Flockhart
Oct 17, 2007·Journal of Cancer Research and Clinical Oncology·Guenter HofmannPeter Krippl

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw
genotyping

Software Mentioned

tagSNPS

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.