Polymorphisms in the vitamin D receptor and their associations with risk of schizophrenia and selected anthropometric measures

American Journal of Human Biology : the Official Journal of the Human Biology Council
H Y HandokoJohn J McGrath

Abstract

The association between vitamin D levels and skeletal growth has long been recognized. However, exposure to low levels of vitamin D during early life is also known to alter brain development, and is a candidate risk factor for schizophrenia. This study examines the association between four polymorphisms in the vitamin D receptor (VDR) and 1) risk of schizophrenia, and 2) three anthropometric variables (height, head size, and head shape). Four single-nucleotide polymorphisms (SNPs; rs10735810/FokI, rs1544410/BsmI, rs7975232/ApaI, and rs731236/TaqI) in the VDR gene were genotyped in 179 individuals with schizophrenia and 189 healthy controls. No significant associations were detected between any of the four VDR SNPs and risk of schizophrenia. Patients were slightly but significantly shorter compared to controls. Of the four SNPs, only rs10735810/FokI was associated with any of the anthropometric measures: the M4 isoform of this SNP was significantly associated with larger head size (P = 0.002). In light of the evidence demonstrating a role for vitamin D during brain development, the association between polymorphisms in VDR and brain development warrants closer scrutiny.

References

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Citations

Mar 13, 2009·Briefings in Functional Genomics & Proteomics·Anastasia K Yocum, Arul M Chinnaiyan
Oct 3, 2008·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Stuart MacgregorDorret I Boomsma
Aug 14, 2009·Nutrition Reviews·Elizabeth R Bertone-Johnson
Jun 8, 2013·Pharmacological Reports : PR·Małgorzata WrzosekGrażyna Nowicka
Jul 22, 2009·Journal of Psychiatric Research·Chun-Jung HuangEl-Wui Loh
Jun 24, 2010·Behavioural Pharmacology·Adam StewartAllan V Kalueff
Dec 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joyce C McCann, Bruce N Ames
Jun 12, 2018·Molecular Neuropsychiatry·Shan-Yuan TsaiCynthia Shannon Weickert
Sep 10, 2020·International Journal of Paediatric Dentistry·Mariane C F BarbosaDaniela S B de Oliveira

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