Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study.

BMC Cancer
Vibeke AndersenUlla Vogel

Abstract

The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Cyclooxygenase-2 (COX-2) derived prostaglandins promote gastrointestinal carcinogenesis, affecting angiogenesis, apoptosis, and invasiveness.The aim of this study was to investigate if polymorphisms in these genes were associated with risk of colorectal cancer (CRC), and to investigate possible interactions with lifestyle factors such as smoking, meat consumption, and NSAID use. The following polymorphisms were analyzed; a synonymous MDR1 C3435T (rs1045642) in exon26, G-rs3789243-A in intron3, the functional BCRP C421A (rs2231142), the two COX-2 A-1195G (rs689466) and G-765C (rs20417) in the promoter region, and the COX-2 T8473C (rs5275) polymorphisms in the 3'-untranslated region. The polymorphisms were assessed together with lifestyle factors in a nested case-cohort study of 359 cases and a random cohort sample of 765 participants from the Danish prospective Diet, Cancer and Health study. Carriers of the variant allele of MDR1 intron 3 polymorphism were at 1.52-fold higher ris...Continue Reading

References

Dec 1, 1991·International Journal of Epidemiology·A TjønnelandO M Jensen
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
May 20, 1999·Annual Review of Pharmacology and Toxicology·S V AmbudkarM M Gottesman
Dec 2, 1999·Journal of Clinical Epidemiology·W E BarlowS Izumi
Jan 19, 2000·Trends in Biochemical Sciences·R W JohnstoneM J Smyth
Mar 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·S HoffmeyerU Brinkmann
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christina ZiemannKaren I Hirsch-Ernst
Jul 26, 2002·The Journal of Biological Chemistry·Vimal A PatelAndrey Sorokin
May 15, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Aqel W Abu-QareMohamed B Abou-Donia
Aug 2, 2003·Pharmacogenetics·Deanna L KroetzUNKNOWN Pharmacogenetics of Membrane Transporters Investigators
Nov 25, 2003·Gut·C G DietrichR P J Oude Elferink
Jun 3, 2004·British Journal of Cancer·D G CoxUNKNOWN Bellvitge Colorectal Cancer Study Group
Jun 26, 2004·Clinical Pharmacokinetics·Ichiro IeiriKenji Otsubo
Aug 19, 2004·The Journal of Allergy and Clinical Immunology·Wojciech SzczeklikAndrew Szczeklik
Mar 16, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Cornelia M UlrichJeannette Bigler
Apr 23, 2005·Toxicology and Applied Pharmacology·Elaine M LeslieSusan P C Cole
May 25, 2005·European Journal of Clinical Pharmacology·Mateusz KurzawskiJan Lubiński
Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Marek SanakAndrew Szczeklik
Jul 12, 2005·Pharmacogenetics and Genomics·Stefano LandiUNKNOWN Bellvitge Colorectal Cancer Study Group
Aug 11, 2005·The Journal of Clinical Endocrinology and Metabolism·Maria Chiara ZatelliEttore C degli Uberti
Aug 17, 2005·Circulation·Matthias HermannFrank Ruschitzka
Sep 6, 2005·Pharmacogenetics and Genomics·Danxin WangWolfgang Sadée
Dec 6, 2006·European Journal of Clinical Pharmacology·Elena OsswaldKarla Köpke
Dec 13, 2006·European Journal of Epidemiology·Nina Føns JohnsenAnne Tjønneland
Mar 17, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·U L LarsenV Andersen
May 15, 2007·Lancet·Enrico FlossmannUNKNOWN British Doctors Aspirin Trial and the UK-TIA Aspirin Trial
May 19, 2007·Cancer Research·Ornella FantappièRoberto Mazzanti
May 25, 2007·The New England Journal of Medicine·Andrew T ChanCharles S Fuchs
Feb 22, 2008·Current Drug Metabolism·Takaharu MizutaniKazuhiko Takahashi

❮ Previous
Next ❯

Citations

Mar 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li ZhaoZhen Yang
Mar 10, 2011·The Proceedings of the Nutrition Society·Elizabeth K LundIan T Johnson
Jan 3, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T HeL Liu
Feb 16, 2013·Journal of Clinical Bioinformatics·Li-Yeh ChuangCheng-Hong Yang
Aug 27, 2013·PloS One·Vibeke AndersenLotte K Vogel
Sep 12, 2013·PloS One·Xiao-feng WangWei-jian Guo
Sep 3, 2010·The Tohoku Journal of Experimental Medicine·Hui CaoShao-lin Li
Apr 30, 2014·Archives of Toxicology·Márton JaniPéter Krajcsi
Aug 5, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kassogue YayaNadifi Sellama
Feb 24, 2012·Journal of Cancer Research and Clinical Oncology·Jun WangJianshi Di
Mar 21, 2012·Scandinavian Journal of Gastroenterology·Vibeke AndersenUlla Vogel
Sep 21, 2013·Expert Opinion on Therapeutic Targets·Ioly Kotta-LoizouStamatios Theocharis
Dec 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Houshiyar GhafouriAbdolhakim Hoseini
Jul 15, 2015·Cancer Epidemiology·Teresa NoratIsabelle Romieu
Oct 31, 2014·Journal of Biomedical Science·Marcella MartinelliRossella Solmi
Dec 12, 2012·Alimentary Pharmacology & Therapeutics·V AndersenU Vogel
Apr 29, 2015·Pharmacogenomics·José A G AgúndezElena García-Martín
Apr 7, 2015·Current Nutrition Reports·Elizabeth D Kantor, Edward L Giovannucci
Feb 9, 2017·Archives of Toxicology·Thomas Efferth, Manfred Volm
Mar 22, 2014·Inflammatory Bowel Diseases·Ashwin N AnanthakrishnanRamnik J Xavier
Dec 11, 2014·Genes & Nutrition·Vibeke Andersen, Ulla Vogel

❮ Previous
Next ❯

Methods Mentioned

BETA
hormone replacement therapy
PCR
genotyping
hormone

Software Mentioned

FoodCalc
MxPro
SAS

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.