Polymorphisms in toll-like receptor 1 and 9 genes and their association with tuberculosis susceptibility in Chinese Holstein cattle

Veterinary Immunology and Immunopathology
Liping SunLiguo Yang

Abstract

Toll-like receptors (TLRs) are a class of pattern recognition receptors that play a pivotal role in the innate and adaptive immune systems. Studies have shown that TLR variants play roles in various human infectious diseases. The aim of the present study was to investigate whether the functional genetic variations at positions C632T, G1409A, A1475C, G1550A and G1596A in TLR1 and at A2700G and A3156G in TLR9 confer susceptibility or resistance to bovine tuberculosis (bTB). Genotyping of the TLR1 and TLR9 gene polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and single-strand conformation polymorphism (PCR-SSCP) in 586 Chinese Holstein cows (154 infected with bTB, 432 non-infected). The frequencies of the GH and HH genotypes at TLR1-G1596A differed significantly between bTB-infected and non-infected animals [p=0.001 for both GH and HH; GH odds ratio (OR)=2.43 95% confidence interval (CI) (1.47-4.03); and HH OR=1.49 95% CI (0.85-2.62)]. There was a trend toward an increased relative risk of tuberculosis (TB) incidence in the CD genotype at the TLR1-A1475C locus [p=0.056, OR=1.59 95% CI (0.98-2.58)]. The present study suggests that variants in the TLR1 gene are associated ...Continue Reading

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Citations

Feb 8, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiong DaiZhi Hui Yang
Sep 24, 2014·Journal of Comparative Pathology·J P Cassidy, A R Martineau
May 31, 2014·Research in Veterinary Science·Julio AlvarezAndrés Pérez
Oct 16, 2015·The Journal of Veterinary Medical Science·Yafen ChengHsiang-Jung Tsai
Jun 13, 2013·Physiological Genomics·Nikki le RoexEileen G Hoal
Mar 2, 2017·Veterinary World·B M PrajapatiJ D Chaudhari
Jan 29, 2014·Molecular Biology Reports·Om PrakashDeepak Sharma
Feb 16, 2016·The Journal of Veterinary Medical Science·Yafen ChengHsiang-Jung Tsai
Jun 3, 2021·Genes·Thais Miranda Silva FreitasMaria Clorinda Soares Fioravanti

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