Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups

Leukemia Research
Phillip J MüllerDeborah Rund

Abstract

Drug metabolism/disposition and transporter genes may influence predisposition or prognosis of AML (acute myeloid leukemia) patients. We analyzed polymorphisms in 3 transporters and 4 drug metabolism genes in 293 Israeli individuals (112 AML patients and 181 controls). We analyzed: ABCC3 (MRP3) C-211T; ABCG2 (BCRP) C421A; CNT1 (SLC28A1) G565A and NAT1, NAT2, and GSTT1 and GSTM1 null alleles for influence on predisposition, as well as treatment response and survival. We found that the ABCC3 C-211T polymorphism and GSTM1 null genotype have adverse prognostic significance in AML. None of the other polymorphisms studied were found to influence either predisposition or prognosis in Israeli AML patients.

References

Dec 18, 1996·Journal of the National Cancer Institute·A HirvonenH Vainio
Jun 27, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Gareth J Morgan, Martyn T Smith
Aug 3, 2002·Leukemia & Lymphoma·Dorina M van der KolkEdo Vellenga
Jan 30, 2003·American Journal of Hematology·Ronny AlcalaiOra Paltiel
Jul 12, 2003·Pflügers Archiv : European journal of physiology·Jennifer H GrayKathleen M Giacomini
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Shinji MizuaraiHidehito Kotani
Feb 24, 2004·Molecular Pharmacology·Jennifer H GrayKathleen M Giacomini
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Xavier FarréMarçal Pastor-Anglada
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zineb BenderraOllivier Legrand
Dec 21, 2004·Leukemia Research·Bertil UgglaUlf Tidefelt
May 3, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Zheng Ye, Honglin Song
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zineb BenderraOllivier Legrand
Nov 15, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Timothy R Rebbeck, Pamela Sankar
Dec 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine L A PlasschaertEdo Vellenga
Jan 3, 2006·Cancer Letters·P BorstK van de Wetering
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·Meyling H CheokWilliam E Evans
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·P Krishnamurthy, J D Schuetz
Jun 14, 2006·Pharmacogenomics·Kevin L GundersonRichard Shen
Nov 28, 2006·Lancet·Elihu Estey, Hartmut Döhner
Jun 22, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Tayseer K EyadaMahmoud K El Masry

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Citations

May 17, 2013·Journal of Human Genetics·Sook Wah YeeCharalambos Andreadis
Oct 25, 2008·Human Molecular Genetics·R Stephanie HuangM Eileen Dolan
May 31, 2012·Pharmacogenetics and Genomics·Caroline F ThornTeri E Klein
May 26, 2011·Genome Biology·Eric R GamazonNancy J Cox
May 28, 2010·Pharmacogenomics·Ekaitz Errasti-Murugarren, Marçal Pastor-Anglada
May 31, 2011·Pharmacogenomics·Bruno Stieger, Peter J Meier
Apr 30, 2014·Archives of Toxicology·Márton JaniPéter Krajcsi
Aug 26, 2014·Japanese Journal of Clinical Oncology·Hai-Rong HeJun Lu
Nov 9, 2014·Expert Opinion on Drug Metabolism & Toxicology·Lori W E van der SchoorJohan W Jonker
Aug 28, 2014·Expert Opinion on Drug Metabolism & Toxicology·Oliver Bruhn, Ingolf Cascorbi
Jan 24, 2009·Clinical Biochemistry·Maria TimofeevaAngela Risch
Sep 16, 2008·Journal of the Neurological Sciences·Ariel MillerTamar Paperna
Dec 25, 2008·International Journal of Cancer. Journal International Du Cancer·Phillip J MüllerAngela Risch
Apr 23, 2011·Drug Metabolism and Pharmacokinetics·Tomohiro SasakiIchiro Ieiri
Mar 26, 2013·Cancer Epidemiology·Jesse D TroyJennifer R Grandis
Feb 24, 2015·Current Hematologic Malignancy Reports·Lara E Sucheston-CampbellTheresa Hahn
Jul 7, 2016·Pharmacogenomics·Juan Eduardo Megías-VericatSalvador F Aliño
May 29, 2014·Drug Metabolism and Drug Interactions·Yao YangStuart A Scott
Mar 6, 2021·Critical Reviews in Oncology/hematology·Flavia Cunha VasconcelosRaquel Ciuvalschi Maia
Mar 15, 2021·Current Problems in Cancer·Aleksandra ButrymGrzegorz Mazur

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