Polymorphisms in XPC and ERCC2 genes, smoking and breast cancer risk

International Journal of Cancer. Journal International Du Cancer
Roy E ShoreIsaac Wirgin

Abstract

To evaluate the associations of breast cancer risk with polymorphisms in the XPC and XPD/ERCC2 DNA nucleotide excision repair genes, a case-control study nested within a prospective cohort of 14,274 women was conducted. Genotypes were characterized for 612 incident, invasive breast cancer cases and their 1:1 matched controls. The homozygous variant of a poly(AT) insertion/deletion polymorphism in intron 9 of the XPC gene (XPC-PAT+/+), was associated with breast cancer risk [odds ratio (OR) = 1.45, 95% confidence interval: 1.07-1.97], after adjustment for other breast cancer risk factors. The breast cancer risk associated with XPC-PAT+/+ did not differ by age at diagnosis. There was an indication of an interaction (p = 0.08) between the XPC-PAT+/+ genotype and cigarette smoking. Ever smokers with the XPC-PAT+/+ genotype were at elevated risk of breast cancer (OR = 1.56, CI: 0.95-2.58), but no differences were observed among never smokers. Analyses of the ERCC2 Lys751Gln polymorphism did not show an association with breast cancer risk, either overall or at younger ages. The results suggest that breast cancer risk is related to the XPC haplotype tagged by the XPC-PAT+/+ insertion-deletion polymorphism in intron 9. Further study of...Continue Reading

References

Feb 20, 1999·American Journal of Epidemiology·I KatoA Zeleniuch-Jacquotte
Mar 5, 1999·Mutation Research·S S Hecht
Dec 21, 2002·International Journal of Cancer. Journal International Du Cancer·Rajiv KumarKari Hemminki
Dec 23, 2003·Carcinogenesis·Somali SanyalKari Hemminki
Sep 15, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Z HuH Shen
Jul 9, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lianping ZhangWenhai Yan
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Bettina KuschelPaul D P Pharoah
Sep 21, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jing ShenMary Beth Terry
Oct 21, 2006·Carcinogenesis·Yimin ZhuXifeng Wu
Oct 13, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jie LinXifeng Wu

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Citations

Jul 17, 2012·Biochemical Genetics·Marta Wlodarczyk, Grazyna Nowicka
Jan 30, 2010·Breast Cancer Research and Treatment·Zheng JiangXishan Wang
Mar 6, 2010·Breast Cancer Research and Treatment·Li-Xin QiuXi-Chun Hu
Apr 10, 2010·Breast Cancer Research and Treatment·Noel PabalanHilmi Ozcelik
Feb 15, 2011·Breast Cancer Research and Treatment·Wei ZhengHua-Wei Zou
Apr 8, 2011·Breast Cancer Research and Treatment·Fang WangGuo-Ping Sun
May 10, 2011·Breast Cancer Research and Treatment·Feng XuYu Zhu
Jan 30, 2010·Carcinogenesis·Ourania KostiYun-Ling Zheng
Jun 8, 2010·Biostatistics·Mengling LiuAnne Zeleniuch-Jacquotte
Jul 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xi-Dai LongGuo-Hui Fu
Apr 6, 2011·Molecular Carcinogenesis·Minkyo SongDaehee Kang
Apr 27, 2011·Environmental and Molecular Mutagenesis·Jana SlyskovaPavel Vodicka
Jan 1, 2011·Oncology Letters·Mani SamsonThangarajan Rajkumar
Apr 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jennifer BrooksIsaac Wirgin

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