Abstract
This study evaluated the potential effects of beta-adrenoceptor (beta-AR) and natriuretic peptide receptor (NPR) gene polymorphisms on the susceptibility to and the severity of idiopathic dilated cardiomyopathy (IDCM) in a Chinese cohort. Ten polymorphisms in the coding regions of beta1-AR, beta2-AR, beta3-AR, NPR1, and NPR2 were genotyped in 430 IDCM patients and 468 healthy subjects. Patients with IDCM were followed for 2 years. In multi-loci combined subtype analysis, the combined profile of beta-AR and NPR was significantly different between IDCM patients and controls (P < .0001), mainly influenced by 2 loci beta1-Ser49Gly and NPR2-C2077T, which were also associated with the severity of IDCM. In single-loci analysis, allele frequencies of beta1-Gly49, NPR1-Glu939, and NPR2-T2077 were higher in patients with IDCM than in controls. Genotypes carrying NPR2-T2077 allele showed 1.94-fold independent risk for IDCM phenotype than C2077 homozygote (P < .001). Carriers of the NPR2-T2077 or beta1-Gly49 variant had worse New York Heart Association functional class or echocardiographic results and elevated serum brain natriuretic peptide, experienced severe symptoms, and required intensive medications and frequent hospitalization for h...Continue Reading
References
Aug 1, 1991·Clinical Cardiology·R DiBianco
Oct 5, 1988·The American Journal of Cardiology·M J Sole, C C Liew
Nov 1, 1983·The American Journal of Cardiology·G L PierpontJ N Cohn
Aug 16, 1994·Biochemistry·S A GreenS B Liggett
Feb 1, 1993·Circulation·A P MaggioniG Tognoni
Jun 1, 1994·Hypertension·C M WeiJ C Burnett
Mar 1, 1996·Circulation·P RichardsonP Nordet
May 1, 1996·Circulation·G EisenhoferM D Esler
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·J TurkiS B Liggett
Mar 27, 1999·Lancet·A MaqboolA J Balmforth
Apr 23, 1999·The Journal of Biological Chemistry·D A MasonS B Liggett
May 4, 2000·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·S PodlowskiG Wallukat
Aug 11, 2000·European Journal of Heart Failure·M KomajdaF Tesson
Mar 29, 2001·Circulation·S MoniotteJ L Balligand
Jul 10, 2001·American Journal of Human Genetics·J Schönberger, C E Seidman
Jul 21, 2001·Journal of Human Hypertension·D RahmutulaY Ozawa
Jan 16, 2002·Journal of Cardiovascular Pharmacology·Deborah A RathzStephen B Liggett
May 30, 2002·The Journal of Biological Chemistry·Malin C LevinYvonne Magnusson
Jun 4, 2002·Endocrine·Dolkun RahmutulaYukio Ozawa
Dec 17, 2002·Human Genetics·Joshua W KnowlesNobuyo Maeda
Jul 2, 2003·Pharmacogenetics·David M KayeDianne Holst
Mar 16, 2004·Stroke; a Journal of Cerebral Circulation·Speranza RubattuMassimo Volpe
Mar 17, 2004·Circulation·Chia-Ti TsaiYung-Zu Tseng
Oct 7, 2004·The American Journal of Medicine·Cinzia ForleoMaria Vittoria Pitzalis
Jun 3, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·W PollerH-P Schultheiss
Feb 7, 2006·Journal of Theoretical Biology·Jason H MooreBill C White
Aug 2, 2007·Journal of Cardiovascular Medicine·Cinzia ForleoMariavittoria Pitzalis
Sep 4, 2007·Journal of the American College of Cardiology·Geoffrey S GinsburgJeanette J McCarthy
Apr 26, 2008·European Journal of Heart Failure·Michael WeberGerd Geisslinger
Citations
Jul 21, 2012·PloS One·Wen-Nan LiuMing Zhong
Mar 13, 2014·Clinical Science·Speranza RubattuMassimo Volpe
Sep 23, 2016·PloS One·Chin LinSui-Lung Su
Jan 16, 2016·The Journal of International Medical Research·Mengqi GuoXiaoping Ji
May 10, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Aldo ClericoClaudio Passino
May 10, 2011·Molecular Biology Reports·Bo JinHuan-Chun Ni
Mar 31, 2016·Pacing and Clinical Electrophysiology : PACE·Luisa ZanollaGiuseppe Matullo