Polymorphisms of chicken TLR3 and 7 in different breeds

PloS One
Wenke RuanYanhua Wu

Abstract

Toll-like receptors (TLRs) mediate immune responses via the recognition of pathogen-associated molecular patterns (PAMPs), thus playing important roles in host defense. Among the chicken (Ch) TLR family, ChTLR3 and 7 have been shown to recognize viral RNA. In our earlier studies, we have reported polymorphisms of TLR1, 2, 4, 5, 15 and 21. In the present study, we amplified TLR3 and 7 genes from different chicken breeds and analyzed their sequences. We identified 7 amino acid polymorphism sites in ChTLR3 with 6 outer part sites and 1 inner part site, and 4 amino acid polymorphism sites in ChTLR7 with 3 outer part sites and 1 inner part site. These results demonstrate that ChTLR genes are polymorphic among different chicken breeds, suggesting a varied resistance across numerous chicken breeds. This information might help improve chicken health by breeding and vaccination.

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Citations

Feb 6, 2020·Veterinary Sciences·Sabari Nath Neerukonda, Upendra Katneni
Nov 12, 2018·Archives Animal Breeding·Santosh HaunshiRudra Nath Chatterjee
Jan 11, 2021·Developmental and Comparative Immunology·Jiandong YangMing Zhang
Jan 24, 2021·Research in Veterinary Science·Zhaobo ZhangLiping Han

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Datasets Mentioned

BETA
KM486593
KM486594
KM486595
KM486596
KM486598
KM486600
KM486601
KM486602
KM486603
KM486605

Methods Mentioned

BETA
PCR

Software Mentioned

PyMOL
MegAlign
CPHmodels

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