Polymorphisms of clotting factors modify the risk for primary intracranial hemorrhage.

Blood
J CorralV Vicente

Abstract

Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, but few genetic risk factors have been associated with its development. Recently, it has been reported that some polymorphisms that affect clotting factors increase the risk for thrombosis. However, reports have analyzed the effect of polymorphisms influencing the hemostatic state in bleeding disorders insufficiently. A case-control study was conducted of 201 patients with spontaneous intracranial hemorrhage and 201 control subjects matched for age, race, sex, and selected risk factors (hypertension, smoking, and alcohol consumption). Genomic polymerase chain reaction was used to analyze the prevalence of 4 polymorphisms: factor V Leiden, prothrombin 20210A, factor VII-323 Del/Ins of a decanucleotide, and factor XIII V34L. Subjects with factor V Leiden had decreased risk for spontaneous intracranial hemorrhage (odds ratio, 0.19; 95% confidence interval, 0.03-0.95). The frequency of the prothrombin 20210A/G genotype was also lower among patients than controls (1.5% vs 3%, respectively). Moreover, carriers of the -323 Ins allele of factor VII had a 1.54-fold risk for intracranial hemorrhage (95% CI, 1.03-2.72). Finally, no significant differences...Continue Reading

References

Apr 1, 1989·Cardiovascular Drugs and Therapy·P P Nawroth, D M Stern
Oct 28, 1995·Lancet·D C ReesJ B Clegg
Dec 8, 1994·The New England Journal of Medicine·K A Hajjar
Sep 1, 1994·The Journal of Clinical Investigation·B Dahlbäck
May 5, 1994·Nature·P W Majerus
Feb 1, 1994·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·L P BergD N Cooper
Jan 8, 1998·The New England Journal of Medicine·L IacovielloM Benedetta Donati
Apr 29, 1998·Stroke; a Journal of Cerebral Circulation·A J CattoP J Grant
Oct 10, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·P E Petrides, W M Nauseef
Oct 17, 1998·Current Opinion in Hematology·R M Bertina
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Ingerslev, H L Kristensen
Nov 25, 2000·British Journal of Haematology·R F FrancoP H Reitsma

❮ Previous
Next ❯

Citations

Jun 10, 2010·Annals of Hematology·Ana I AntónDiego Mezzano
Oct 24, 2007·Journal of Thrombosis and Thrombolysis·Elizabeth A Varga
Feb 20, 2008·Internal and Emergency Medicine·Massimo Franchini, Pier Mannuccio Mannucci
Mar 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Georg Endler, Christine Mannhalter
Dec 19, 2002·European Journal of Clinical Investigation·C P Gale, P J Grant
Mar 13, 2012·Neurology India·Baoqiong LiuQidong Yang
Mar 15, 2006·Current Opinion in Anaesthesiology·Chanhung Z Lee, William L Young
Mar 3, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Jacqueline A CutlerGeoffrey F Savidge
Aug 12, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A GirolamiE Zanon
Dec 17, 2015·Nature Reviews. Neurology·Amanda M CarpenterCharles J Prestigiacomo
Nov 26, 2009·Thrombosis Research·Massimo Franchini, Giuseppe Lippi
Apr 26, 2013·Thrombosis and Haemostasis·Thijs E van MensSaskia Middeldorp
Sep 27, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L A RamenghiF Mosca
Mar 30, 2007·British Journal of Haematology·Javier CorralVicente Vicente
Aug 29, 2007·Journal of Thrombosis and Haemostasis : JTH·J López-SagasetaJ Hermida
Sep 21, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S GreiseneggerC Mannhalter
Nov 18, 2014·Journal of Thrombosis and Haemostasis : JTH·R Teruel-MontoyaC Martínez
Oct 12, 2013·Thrombosis Research·Anna K DonovanMargaret V Ragni
Jan 30, 2015·Journal of Clinical Neurology·Constantino MartínezJosé Rivera
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Steven M Greenberg
Nov 8, 2001·Blood·J N Hagstrom
Aug 28, 2004·Stroke; a Journal of Cerebral Circulation·Juan A IniestaJavier Corral
Dec 12, 2001·Stroke; a Journal of Cerebral Circulation·M WegerA Haas
May 23, 2007·Molecular Biology Reports·Rami A R MahfouzAli T Taher
Sep 14, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Shadi TabibianAkbar Dorgalaleh

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