Polymorphisms of coagulation/fibrinolysis genes: gene environment interactions and vascular risk

Prostaglandins, Leukotrienes, and Essential Fatty Acids
P J Grant

Abstract

Circulating concentrations of plasminogen activator inhibitor-1 (PAI-1), factor VII and fibrinogen have all been related to vascular risk in large prospective studies. Evidence indicates that all three proteins are increased in the presence of insulin resistance and factor VII and PAI-1 correlate strongly with circulating levels of insulin and lipids. Polymorphisms of the genes coding for PAI-1, factor VII and fibrinogen have been investigated in relation to gene environment interactions and vascular risk. Three polymorphisms have been described in the PAI-1 gene, a 3' Hind III RFLP, an intronic CA repeat and a 4G/5G insertion deletion 675 bp 5' of the start site of transcription. The 4G/5G site has been shown to be triglyceride responsive and higher levels of PAI-1 have been reported in subjects homozygous for the 4G allele. Three out of four case control studies have related possession of the 4G/4G genotype to an increased risk of coronary artery disease and our studies in patients undergoing coronary angiography indicate that this is due to increased myocardial infarction rather than atheroma. We have investigated 600 subjects with cerebrovascular disease and found no relationship to the 4G/5G polymorphism. Two major polymor...Continue Reading

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Citations

Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·I Mertens, L F Van Gaal
Mar 6, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yi ZengXiaoPing Du
May 13, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Didem ArmangilAytemiz Gürgey
May 21, 2018·Journal of Thrombosis and Haemostasis : JTH·T UranoY Suzuki
Aug 6, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jingtao LuPatricia E Ganey
Nov 11, 1999·Current Opinion in Lipidology·T G DeLoughery

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