Polymorphisms of GLP-1 receptor gene and response to GLP-1 analogue in patients with poorly controlled type 2 diabetes

Journal of Diabetes Research
Chia-Hung LinChi-Neu Tsai

Abstract

The relationship between genetic polymorphisms of the glucagon-like peptide-1 (GLP-1) receptor (GLP1R) gene and unresponsiveness to GLP-1 analogue treatment in patients with poorly controlled type 2 diabetes mellitus (DM) is unclear. Thirty-six patients with poorly controlled type 2 DM were enrolled and they received six days of continuous subcutaneous insulin infusion for this study. After the normalization of blood glucose in the first 3 days, the patients then received a combination therapy with injections of the GLP-1 analogue, exenatide, for another 3 days. All 13 exons and intron-exon boundaries of the GLP1R gene were amplified to investigate the association. The short tandem repeat at 8GA/7GA (rs5875654) had complete linkage disequilibrium (LD, with r2 = 1) with single nucleotide polymorphism (SNP) rs761386. Quantitative trait loci analysis of GLP1R gene variation with clinical response of GLP1 analogue showed the missense rs3765467 and rs761386 significantly associated with changes in the standard deviation of plasma glucose (SDPG(baseline) - SDPG(treatment with GLP-1 analogue)) (P = 0.041 and 0.019, resp.). The reported P values became insignificant after multiple testing adjustments. The variable response to the GLP-1...Continue Reading

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Citations

Jul 27, 2017·The Journal of Gene Medicine·Sally M ShalabyRehab H El-Sokkary
Sep 24, 2020·International Journal of Molecular Sciences·Yulia A NasykhovaAndrey S Glotov
Aug 29, 2019·Drug Metabolism Reviews·Adriana FodorGabriela Roman
Aug 26, 2019·Journal of Molecular Biology·Alejandra TomasColin Leech
Feb 18, 2021·Diabetologia·Wolfgang Rathmann, Brenda Bongaerts
Oct 18, 2020·Molecular Metabolism·Michael A NauckJuris J Meier
Jun 10, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Tiantian XuJing Wu
Aug 10, 2021·Diabetes & Metabolic Syndrome·Zhichun Guo, Ronny Priefer
May 12, 2016·Pharmacogenomics·Ivan Tkáč, Ivana Gotthardová
Nov 9, 2017·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P GargiuloP Perrone-Filardi

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Datasets Mentioned

BETA
AL035690

Methods Mentioned

BETA
PCR
electrophoresis

Clinical Trials Mentioned

NCT01473147
NCT02026024

Software Mentioned

MATLAB
SPSS

Related Concepts

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Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.

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