Polymorphisms of glutathione S-transferase A1 and O1 and breast cancer among postmenopausal Danish women

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Anja OlsenAnne Tjønneland

Abstract

The glutathione S-transferase (GST) family of enzymes is involved in the protection of the cell against foreign compounds and may consequently play a role in the development of cancer. Two of the family members, GSTA1 and GSTO1, have only been considered in a very limited number of studies. The objective of this study was to evaluate the potential relationships between GSTA1 and GSTO1 polymorphisms and breast cancer, taking into account the estrogen receptor statuses of the tumors and potential interactions with smoking, and intake of fruits and vegetables. The basis for the study was a nested case-control study including 396 postmenopausal pairs. Genetic polymorphisms were determined by restriction-fragment length polymorphism-polymerase chain reaction methods, and risks for breast cancer were estimated using conditional logistic regression. No association between GSTA1 polymorphism and breast cancer was found whereas carriers of the GSTO1 *B/*B genotype had higher risks of breast cancer when compared with carriers of the GSTO1 *A/*A genotype (incidence rate ratio 1.62, 95% confidence interval: 1.01-2.61). This association was strongest with regard to estrogen receptor positive breast cancer (incidence rate ratio 2.16, 95% con...Continue Reading

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Citations

Oct 28, 2009·Breast Cancer Research and Treatment·Irena E AndonovaHiltrud Brauch
Aug 2, 2011·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Juhua ZhouMitzi Nagarkatti
Jan 19, 2010·Expert Opinion on Drug Metabolism & Toxicology·Giuliano Di PietroFabrício Rios-Santos
Jul 19, 2014·Ukrainskiĭ biokhimicheskiĭ zhurnal·O M Fedets
Jul 28, 2011·International Journal of Cancer. Journal International Du Cancer·Petra SeiboldJenny Chang-Claude
Apr 6, 2011·Molecular Carcinogenesis·Minkyo SongDaehee Kang
Feb 2, 2010·Annals of Human Biology·Renato PolimantiMaria Fuciarelli
Aug 11, 2010·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Nina RoswallAnne Tjønneland

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