Polymorphisms of homologous recombination RAD51, RAD51B, XRCC2, and XRCC3 genes and the risk of prostate cancer

Analytical Cellular Pathology (Amsterdam)
Maria Nowacka-ZawiszaWanda M Krajewska

Abstract

Genetic polymorphisms in DNA repair genes may induce individual variations in DNA repair capacity, which may in turn contribute to the risk of cancer developing. Homologous recombination repair (HRR) plays a critical role in maintaining chromosomal integrity and protecting against carcinogenic factors. The aim of the present study was to evaluate the relationship between prostate cancer risk and the presence of single nucleotide polymorphisms (SNPs) in the genes involved in HRR, that is, RAD51 (rs1801320 and rs1801321), RAD51B (rs10483813 and rs3784099), XRCC2 (rs3218536), and XRCC3 (rs861539). Polymorphisms were analyzed by PCR-RFLP and Real-Time PCR in 101 patients with prostate adenocarcinoma and 216 age- and sex-matched controls. A significant relationship was detected between the RAD51 gene rs1801320 polymorphism and increased prostate cancer risk. Our results indicate that the RAD51 gene rs1801320 polymorphism may contribute to prostate cancer susceptibility in Poland.

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Citations

Jul 24, 2018·Oral Diseases·Edilmar de Moura SantosRoseana de Almeida Freitas
Jan 7, 2020·PloS One·Peter GrešnerJolanta Gromadzińska
Jun 13, 2019·Journal of Oncology·Maria Nowacka-ZawiszaWanda M Krajewska
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sumit KumarRamovatar Meena
Oct 6, 2020·NAR Cancer·McKenzie K GrundyKara A Bernstein

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Methods Mentioned

BETA
genotyping
PCR
biopsies

Software Mentioned

Statistica

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