Polymorphisms of insulin-like growth factor binding protein-3 as a predictor for risk and patient survival in esophageal squamous cell carcinoma

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Lei ZhaoMeng-Zhong Liu

Abstract

Genetic single nucleotide polymorphisms (SNP) play a critical role in the development of esophageal squamous cell carcinoma (ESCC). The aim of this study is to investigate the associations between insulin-like growth factor binding protein-3 (IGFBP-3) gene polymorphisms and ESCC patients risk and survival after definitive chemoradiotherapy (CRT). We undertook a case-control study to analyze two IGFBP-3 polymorphisms (rs2854744 A>C and rs2854746 G>C) in an Han Chinese population, by extraction of genomic DNA from the peripheral blood of 110 ESCC patients treated with CRT and 128 control participants, and performed IGFBP-3 genotyping using DNA sequencing. The obtained results indicated that overall, no statistically significant association was observed in rs2854746 G>C. However, rs2854744 A>C genotype was at increased risk of ESCCs (P=0.032; odds ratio (OR)=1.201, CI 95%:1.014-1.423). Moreover, rs2854744 A>C genotype ESCCs were more significantly common in patients with tumor size of >6cm than A allele ESCC and in cases of lower T stage. Furthermore, ESCC patients with rs2854744CC genotype have the poorer CRT response and shorter survival time than GG+GC genotype ESCC. In conclusion, polymorphism in IGFBP-3 rs2854744 A>C might be...Continue Reading

References

Apr 1, 1994·International Journal of Cancer. Journal International Du Cancer·J HuX Xu
Jan 15, 2005·International Journal of Colorectal Disease·Rajaraman DuraiMarc C Winslet
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Libby M MorimotoJohn D Potter
Dec 23, 2006·Seminars in Radiation Oncology·Mohan Suntharalingam
Feb 22, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Wensen ChenHongbing Shen
Dec 9, 2010·Breast Cancer Research and Treatment·Ann H RosendahlHelena Jernström
Feb 23, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nicholas J OllberdingLoïc Le Marchand

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