Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.

Journal of Clinical Immunology
Yu-Lian JiaoYue-Ran Zhao

Abstract

Accumulating evidences indicate that killer cell immunoglobulin-like receptors (KIRs) and their corresponding specific HLA-C ligands contribute to the pathogenesis of multiple autoimmune diseases via the modulation of natural killer (NK) cell and T cell functions. The present study was performed to investigate whether the polymorphism of KIR genes and HLA ligands associates with the susceptibility of ankylosing spondylitis (AS). Previous studies have demonstrated a strong association between HLA-B27 gene and the pathogenesis of AS. In this study, 115 unrelated HLA-B27-positive AS patients and 119 HLA-B27-positive healthy controls were recruited. Polymerase chain reaction using sequence-specific primers was used to determine the genotypes of KIR genes and HLA-C alleles. The results showed that the frequencies of KIR2DL1 and KIR2DL5 were significantly higher in the AS patient group than those in the control group (p = 0.012 and p = 0.009, respectively). Meanwhile, individuals with AS showed an increased frequency of HLA-Cw*08 (p = 0.001, p (c)  = 0.008) compared with that in controls. Our findings indicate that with the genetic background of HLA-B27, variation at the KIRs and their corresponding specific HLA-C ligands may influen...Continue Reading

References

Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M ColonnaJ L Strominger
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T NamekawaJ J Goronzy
Sep 14, 2001·Current Opinion in Rheumatology·J D ReveilleM A Khan
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maureen P MartinMary Carrington
Mar 12, 2004·Current Molecular Medicine·Anne-Marie SimsMatthew A Brown
Aug 4, 2004·Experimental Gerontology·Lynn D MaxwellDerek Middleton
Aug 6, 2004·Autoimmunity·Hyun-Bae Jie, Nora Sarvetnick
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeroen van BergenFrits Koning
Feb 23, 2008·Neurosurgical Focus·Mohammed F ShamjiEve Tsai
May 21, 2008·Tissue Antigens·M Marcilla, J A López de Castro
Jun 25, 2008·Blood·Emmanuelle Fourmentraux-NevesAnne Caignard

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Citations

Aug 24, 2013·International Journal of Inflammation·José Francisco Zambrano-ZaragozaNorberto Vibanco-Pérez
Jun 19, 2012·Journal of Autoimmunity·Zhigang TianCai Zhang
Aug 5, 2015·Arthritis & Rheumatology·S VendelboschT W Kuijpers
Aug 14, 2012·Tissue Antigens·R Díaz-PeñaC López-Larrea
May 28, 2016·Ocular Immunology and Inflammation·Cailin H Sibley
Jun 2, 2016·Ocular Immunology and Inflammation·Denis WakefieldPeter McCluskey
Dec 22, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Ilijas JelcićJan D Lünemann
Mar 25, 2011·Ocular Immunology and Inflammation·Tammy M Martin, James T Rosenbaum
Aug 30, 2011·Journal of Leukocyte Biology·Olympe ChazaraAshley Moffett
Oct 8, 2020·Journal of Personalized Medicine·Roberto Díaz-PeñaAlejandro Lucia
Mar 16, 2021·Frontiers in Immunology·Umut Can KucuksezerGunnur Deniz
Aug 3, 2021·Frontiers in Genetics·Jessika NordinJennifer R S Meadows
Feb 13, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alireza RezaiemaneshMohammad Hossein Nicknam
Jun 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Negar VanakiMahdi Mahmoudi

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