Polymorphisms of pesticide-metabolizing genes in children living in intensive farming communities

Chemosphere
Antonio Gómez-MartínMarina Lacasaña

Abstract

Polymorphisms in genes encoding xenobiotic-metabolizing enzymes (XME) are important parameters accounting for the wide inter-individual variability to environmental exposures. Paraoxonase-1 (PON1), butyrylcholinesterase (BChE) and Cytochrome-P450 constitute major classes of XME involved in the detoxification of pesticide chemicals, in particular organophosphates. This study explored the allelic frequency, linkage disequilibrium and haplotype analysis of ten common polymorphic variants of seven key genes involved in organophosphate metabolism (BCHE-K, BCHE-A, PON1 Q192R, PON1 L55M, PON1 -108C/T, CYP2C19 G681A, CYP2D6 G1846A, CYP3AP1 -44G/A, GSTM1∗0 and GSTT1∗0) in a children population living near an intensive agriculture area in Spain. It was hypothesized that individuals with unfavorable combinations of gene variants will be more susceptible to adverse effects from organophosphate exposure. Genomic DNA from 496 healthy children was isolated and amplified by PCR. Hydrolysis probes were used for the detection of eight specific SNPs and two copy number variants (CNVs) by using TaqMan® Assay-based real-time PCR. Frequencies of SNPs and CNVs in the target genes were in Hardy-Weinberg equilibrium and broadly consistent with European...Continue Reading

References

Dec 3, 1999·Journal of Clinical Pharmacy and Therapeutics·E Tanaka
Oct 31, 2002·Advanced Drug Delivery Reviews·Jatinder K LambaKenneth E Thummel
Apr 11, 2003·American Journal of Physical Anthropology·M AcuñaE Llop
Jun 6, 2003·Mutation Research·Claudia Bolognesi
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Apr 15, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yi-Jie LiuRuey-Hong Wong
Sep 21, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Regina M Santella
Dec 17, 2008·Toxicology and Applied Pharmacology·Rebecca J RichterClement E Furlong
Apr 23, 2009·The Journal of Biological Chemistry·Erez PodolyHermona Soreq
Jun 12, 2009·Drug Metabolism Reviews·Shu-Feng ZhouBalram Chowbay
May 24, 2011·Toxicology and Applied Pharmacology·Tesifón ParrónRaquel Alarcón
Feb 14, 2013·Toxicology and Applied Pharmacology·Sara Mostafalou, Mohammad Abdollahi
Nov 26, 2013·Toxicology Letters·Tesifón ParrónRaquel Alarcón

❮ Previous
Next ❯

Citations

Oct 17, 2016·International Journal of Cardiology·Jesús Sánchez-RamosJose Cabeza Barrera
Mar 1, 2018·Journal of Translational Medicine·Fernando Estévez-LópezMaría J Álvarez-Cubero
Apr 1, 2017·Journal of Genetics·Gurpreet KaurSandeep Singh
Sep 30, 2020·Nursing Research·Alma RusMaria Jesus Alvarez-Cubero
Mar 17, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·David Lozano-PaniaguaAntonio F Hernández
Mar 28, 2021·Environmental Research·Carmen FreireMariana F Fernández
Nov 28, 2021·Pharmaceutics·David Blánquez-MartínezCristina Lucía Dávila-Fajardo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.