Polymorphisms of renin-angiotensin genes among Nigerians, Jamaicans, and African Americans

Hypertension
C RotimiR Ward

Abstract

Within the context of an international collaborative study of the evolution of hypertension in the black diaspora, we determined the allelic distribution of hypertension candidate genes for the renin-angiotensin system in three populations of African origin. The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) and the M235T and T174M variants of the angiotensinogen (AGT) gene were examined in individuals from Nigeria, Jamaica, and the United States. Large differences in the prevalence of hypertension were recorded in door-to-door surveys, ranging from 16% in Nigeria to 33% in the United States. The frequency of the D allele was similar in all groups (54%, 59%, and 63% in Nigeria, Jamaica, and the United States, respectively). The 235T allele of the AGT gene was found in 81% of US and Jamaican blacks and 91% of Nigerians; very little variation was seen for the T174M marker. Despite large differences in hypertension rates, genetic variation at the index loci among these groups was modest. Overall, the frequency of the ACE*D allele was only slightly higher than that reported for European and Japanese populations, whereas the AGT 235T allele was twice as common. Compared with blacks in the western he...Continue Reading

Associated Clinical Trials

References

Apr 15, 1992·Biochemical and Biophysical Research Communications·R Y ZeeB J Morris
Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Jun 15, 1973·Science·J Adams, R H Ward
Jul 1, 1994·American Journal of Hypertension·D R RutledgeE A Ross
Oct 30, 1993·Lancet·J D Swales
Mar 1, 1994·The Journal of Clinical Investigation·A HataJ M Lalouel
Jun 9, 1994·The New England Journal of Medicine·M CaulfieldA J Clark
Feb 1, 1994·British Journal of Clinical Pharmacology·E J Lee
Dec 15, 1993·Biochemical and Biophysical Research Communications·C L BennettB J Morris
Oct 1, 1993·PCR Methods and Applications·V ShanmugamB K Saha

❮ Previous
Next ❯

Citations

May 2, 2003·Current Hypertension Reports·Deborah A Price, Naomi D L Fisher
Sep 12, 2000·Current Hypertension Reports·X JeunemaitreP Corvol
May 7, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·Hala M RaslanHassan E El-Batae
Jul 25, 2000·British Journal of Clinical Pharmacology·A A Ajayi, A Q Adigun
Mar 7, 2001·Kidney International·D A PriceN K Hollenberg
Jun 2, 2001·The New England Journal of Medicine·UNKNOWN Beta-Blocker Evaluation of Survival Trial InvestigatorsPhilip W Lavori
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·M J MaliarikM C Iannuzzi
May 5, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Huimin YuWenjun Ma
Feb 1, 1997·American Journal of Public Health·R CooperR Wilks
Apr 9, 2001·Psychosomatic Medicine·L Gleiberman
Apr 1, 1999·Journal of Hypertension·J A StaessenR Fagard
Oct 9, 2007·Journal of Hypertension·Claudia Handtrack, Karl F Hilgers
Nov 28, 2001·The American Journal of the Medical Sciences·P A Marshall, C Rotimi
Apr 1, 1999·The American Journal of the Medical Sciences·R Cooper
Jul 14, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·Lillian Gleiberman
Feb 12, 2004·Congestive Heart Failure·Shawna Nesbitt, Ronald G Victor
Feb 8, 2005·Atherosclerosis·W Douglas ScheerJack P Strong
Dec 31, 2005·American Journal of Human Genetics·Kirk E LohmuellerJohn M Braverman
Oct 7, 2004·Neurobiology of Aging·Robert StewartAnthony Mann
Jun 11, 2002·Biochemical and Biophysical Research Communications·Roland RosmondPer Björntorp
Jun 25, 2004·American Heart Journal·Mark A EastChristopher M O'Connor
Jun 12, 2003·European Journal of Heart Failure·Anissa BouzamondoPhilippe Lechat
May 30, 2003·American Journal of Human Genetics·Kenneth M Weiss
Mar 16, 2002·The Annals of Pharmacotherapy·James S Kalus, Jean M Nappi
Feb 13, 2004·Journal of Human Hypertension·M T RobinsonC E Grim
Jul 10, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A LukeR S Cooper
Jun 6, 2018·Molecular Genetics & Genomic Medicine·Adebowale A AdeyemoOlayemi O Omotade

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.