Polymorphisms of the equine major histocompatibility complex class II DRA locus

Tissue Antigens
J J BrownW E R Ollier

Abstract

The full extent of the polymorphism of ELA-DRA in Equidae is not yet known. Given the apparent differences in DRA polymorphisms between Equidae and other species, the aims of this study were to more fully characterize ELA-DRA, determine the extent of gene polymorphism and establish the allele-frequency distribution. An allele reference panel for the second exon of ELA-DRA was established by sequence-based typing of 69 equine DNA samples consisting of various breeds of domestic horse (Equus caballus), together with donkeys (Equus asinus), Grant's zebras (Equus boehmi) and one onager (Equus hemionus). Five of the six previously reported alleles detected using single-strand conformation polymorphism were found: ELA-DRA*0101, ELA-DRA*0201, ELA-DRA*0301, ELA-DRA*0501 (Albright-Fraser DG et al. Polymorphism of DRA among equids. Immunogenetics 1996: 43: 315-7) and ELA-DRA*0601 (GenBank accession number AF5419361). In addition to the previously reported alleles, five novel ELA-DRA alleles were detected within the ELA-DRA allele reference panel. One of these was identified in E. caballus (ELA-DRA*JBH11), one in E. boehmi and E. hemionus (ELA-DRA*JBZ185) and three in E. asinus (ELA-DRA*JBD3, ELA-DRA*JBD17 and ELA-DRA*JBH45). A total of 5...Continue Reading

References

Jan 1, 1991·Immunogenetics·D AlbrightJ G Woodward
Jan 1, 1996·Immunogenetics·D G Albright-FraserE Bailey
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Feb 13, 1999·The Journal of Heredity·J L WagnerR Storb
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Citations

Apr 26, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marie VranovaPetr Horin
Jan 21, 2006·Immunology·Geraldine M O'ConnorClair M Gardiner
Sep 4, 2008·Tissue Antigens·S DíazG Giovambattista
Nov 28, 2016·Immunogenetics·Donald MillerDouglas F Antczak

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