Polymorphisms of the oxytocin receptor gene and overeating: the intermediary role of endophenotypic risk factors

Nutrition & Diabetes
C DavisJames L Kennedy

Abstract

Oxytocin (OXT) is an evolutionarily ancient neuropeptide with strong links to affiliative and prosocial behaviors, and the management of stress. Increases in OXT also tend to decrease food intake, especially of sweet carbohydrates. The social correlates of low OXT levels mesh with the social deficits and stress proneness identified in interpersonal models of overeating, as well as the increased appetite for highly palatable foods typically seen in chronic overeaters. The objectives of this study were to investigate links between polymorphisms of the oxytocin receptor (OXTR) gene and overeating, and to examine OXTR links with relevant endophenotypes of overeating related to reward and stress sensitivity, and to food preferences. The sample comprised 460 adults between the ages of 25 and 50 years recruited from the community, and representing a broad range of body weights. Overeating, reward and punishment sensitivity, and food preferences, were quantified as composite variables using well-validated questionnaires. In addition, seven single-nucleotide polymorphisms (rs237878, rs237885, rs2268493, rs2268494, rs2254298, rs53576, rs2268498) of the OXTR gene were genotyped. Analyses identified a four-marker haplotype that was signifi...Continue Reading

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Citations

Feb 21, 2019·Journal of Neuroendocrinology·Tatsushi Onaka, Yuki Takayanagi
Sep 5, 2018·Current Psychiatry Reports·Franziska PlessowElizabeth A Lawson
Jun 27, 2019·Current Obesity Reports·Cherlyn Ding, Faidon Magkos
Jul 22, 2019·Archives of Gerontology and Geriatrics·Camila Bittencourt JacondinoMaria Gabriela Valle Gottlieb
Jun 7, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Gönül ÇatliAyhan Abacı
Jul 15, 2021·Journal of Eating Disorders·Victoria BurmesterMarta Crous-Bou
Aug 30, 2021·Frontiers in Neuroendocrinology·R G AnversaR M Brown

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Software Mentioned

Haploview
UNPHASED
SPSS Analytics
AMOS
SPSS
QuantStudio

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