Polymorphisms of the Serotonin Transporter Gene and G-Protein β3 Subunit Gene in Korean Children with Irritable Bowel Syndrome and Functional Dyspepsia.

Gut and Liver
Cheong Soo Park, Ji Hyun Uhm

Abstract

Many candidate gene studies have revealed that polymorphisms of the 5'-flanking controlled SERT gene linked polymorphic region (5HTT-LPR) gene and G-protein β3 C825T gene might be associated with functional dyspepsia (FD) and irritable bowel syndrome (IBS). This study was performed to investigate polymorphisms of the 5HTT-LPR gene and G-protein β3 C825T gene in FD and IBS in Korean children. In total, 102 patients with FD, 72 patients with IBS based on the Rome III criteria and 148 healthy controls without gastrointestinal symptoms were included in the study to analyze 5HTT-LPR and G-protein β3 C825T polymorphisms. 5HTT-LPR genotype analysis revealed no signifi cant differences in FD and IBS patients compared with controls. The GNβ3 C825T genotype distribution for CC, CT, and TT was 23.6%, 53.4%, and 23.0% in controls, 36.3%, 38.2%, and 25.5% in FD and 37.5%, 38.9%, and 23.6% in IBS, respectively. The CC genotype was more common in FD and IBS patients than controls (p<0.05). When the IBS patients were grouped according to IBS subtypes, CC genotype GNβ3 C825T was common in diarrhea-dominant IBS, and the TT genotype was common in constipation-dominant IBS (p<0.05). The CC genotype of G-protein β3 C825T may be associated with FD a...Continue Reading

References

Jun 1, 1996·Journal of Neurochemistry·A HeilsK P Lesch
Aug 26, 1998·The American Journal of Gastroenterology·A Morris-YatesG Andrews
Jul 24, 2002·The American Journal of Gastroenterology·Cengiz PataOguz Ulu
Apr 2, 2004·Gastroenterology·Gerald HoltmannNicholas J Talley
Aug 25, 2004·Best Practice & Research. Clinical Gastroenterology·Gerald HoltmannWinfried Siffert
Sep 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Jan Taminiau, Marc Benninga
Feb 9, 2006·The American Journal of Gastroenterology·Christopher E CamilleriRaul Urrutia
May 9, 2006·Gastroenterology·Andrée RasquinLynn S Walker
Oct 17, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J M ParkI-S Chung
Jun 15, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y A SaitoN J Talley
Mar 12, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N van LelyveldM Samsom
Dec 17, 2008·Annals of the New York Academy of Sciences·Laurence J Miller
Feb 25, 2010·BMC Genetics·Tiffany BrunsonQing Song
Mar 27, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H-J LeeC J Jin
May 12, 2011·Digestive Diseases and Sciences·T MarkoutsakiD G Karamanolis

❮ Previous
Next ❯

Citations

Feb 22, 2014·Digestive Diseases and Sciences·Fei DaiJingyun Yang
Apr 9, 2016·Gastroenterology Research and Practice·Yi-Zuo SongQing-Ke Huang
Nov 10, 2015·European Journal of Gastroenterology & Hepatology·Rajan SinghUday C Ghoshal
Feb 15, 2013·Alimentary Pharmacology & Therapeutics·C DaiM Jiang
Apr 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J J GalliganG M Swain
Mar 22, 2014·The Korean Journal of Internal Medicine·Hyuk LeeUNKNOWN Functional Dyspepsia Study Group in the Korean Society of Neurogastroenterology and Motility
Sep 26, 2014·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jong Kyu ParkUNKNOWN Korean Society of Neurogastroenterology and Motility
Jul 20, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K TriantafyllouG D Dimitriadis
Jul 15, 2015·World Journal of Gastroenterology : WJG·Anastasia KourikouKonstantinos Triantafyllou
Jul 20, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yuezhi WangYu Zhang
Jun 17, 2020·World Journal of Gastroenterology : WJG·Qi-Yun XiaoGui-Jun Fei

❮ Previous
Next ❯

Methods Mentioned

BETA
Genotyping
PCR
electrophoresis

Software Mentioned

Genemapper
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.