Polymorphisms of the XPC gene may contribute to the risk of head and neck cancer: a meta-analysis

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yang ZhangZhigang Huang

Abstract

Polymorphisms of the XPC gene have been reported to be associated with an increased risk of head and neck cancer (HNC), though the exact biological effect is still unclear. Genetic association studies (GAS) investigating the associations between three common polymorphisms (PAT, Lys939Gln, and Ala499Val) of the XPC gene and HNC risk have produced contradictory and inconclusive results. The aim of this meta-analysis is to evaluate the contributions of these polymorphisms to the risk of HNC. A literature search was conducted in the PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure databases to indentify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to evaluate the strength of the associations under a fixed- or random-effect model according to heterogeneity test. Twelve case-control studies were included in this meta-analysis with a total of 3,078 HNC patients and 4,311 healthy controls. For XPC PAT, a significant overall association was found under all major genetic models. Stratified analyses further indicated significant associations in the Caucasian, population-based, non-PCR-RFLP, esophageal cancer and oral cancer subgroups. For XPC Lys93...Continue Reading

References

Feb 19, 1987·The New England Journal of Medicine·H S SacksT C Chalmers
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Aug 18, 2004·Trends in Genetics : TIG·Marcus R Munafò, Jonathan Flint
Jan 20, 2005·Environmental and Molecular Mutagenesis·Mihi YangKyung Tae
Dec 24, 2005·International Journal of Hygiene and Environmental Health·Suparp KietthubthewTakafumi Ishida
Jan 6, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tomotaka SugimuraKanji Ishizaki
Feb 10, 2006·JAMA : the Journal of the American Medical Association·Jaime L PetersLesley Rushton
Mar 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Montserrat García-ClosasNathaniel Rothman
Aug 9, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jiaze AnQingyi Wei
May 20, 2008·Lancet·Athanassios ArgirisRobert L Ferris
Mar 12, 2009·Nature Reviews. Molecular Cell Biology·Tom Misteli, Evi Soutoglou
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Oct 7, 2009·International Journal of Epidemiology·Manuela MarronMia Hashibe
Dec 17, 2009·Mutation Research·Daniël O Warmerdam, Roland Kanaar
May 11, 2010·The Lancet Oncology·Shanthi MarurArlene A Forastiere
Dec 17, 2010·Nature Reviews. Cancer·C René LeemansRuud H Brakenhoff
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Feb 15, 2011·Breast Cancer Research and Treatment·Wei ZhengHua-Wei Zou
Apr 8, 2011·Breast Cancer Research and Treatment·Fang WangGuo-Ping Sun
May 17, 2011·Biochemistry. Biokhimii︠a︡·B PascucciE Dogliotti
Aug 17, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brent S RoseLoren K Mell
Aug 26, 2011·Mutation Research·Fulvio RicceriPaolo Vineis
Sep 13, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shadia JalalJohn J Turchi
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 21, 2012·The Journal of Cell Biology·Steven BerginkWim Vermeulen
Jul 6, 2012·Statistics in Medicine·Dan JacksonRichard D Riley
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Geng JiHong-Xia Ma
Dec 28, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan ZhangShengkai Gong
Jan 30, 2013·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Xia JiangKun Chen
Feb 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chuan LiuYajie Wang
Aug 7, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiang-Sheng DaiZhen-Wei Peng

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Citations

Feb 3, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rumaisa RafiqNazir Ahmad Dar
Oct 2, 2020·Acta Medica (Hradec Králové)·Fatemeh AsadianHossein Neamatzadeh
Dec 18, 2019·Mutation Research. Reviews in Mutation Research·Abir ZebianKazem Zibara

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