Polymorphisms of the XRCC1 and XPD genes and breast cancer risk: a case-control study.

Pathology Oncology Research : POR
Lívia KipikasováJán Mojzis

Abstract

The purpose of this case control study was to evaluate the role of X-ray repair cross-complementing group 1 (XRCC1) and xeroderma pigmentosum group D (XPD) genotypes as genetic indicators of susceptibility to breast cancer (BC). We analysed DNA samples from 114 breast cancer patients and 113 control subjects using polymerase chain reaction-restriction fragment length polymorphism. For the single nucleotide polymorphisms in XRCC1 exon 10 (Arg399Gln, G/A) and XPD exon 23 (Lys751Gln, A/C), no remarkable differences for genotype distribution and allele frequencies were observed between BC group and control group in the study. The genotype frequency for homozygote A/A in XPD exon 6 (Arg156Arg, C/A) were significantly different between BC and control groups (P < 0.0001, odds ratio = 2.14; 95% confidence interval 1.44-3.17). The data indicate a possible role for XPD (Arg156Arg, C/A) polymorphisms in BC susceptibility.

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Apr 4, 2001·Carcinogenesis·D ButkiewiczC C Harris
Apr 17, 2001·International Journal of Cancer. Journal International Du Cancer·G MatulloP Vineis
Feb 28, 2002·Cancer Letters·Andrew F OlshanDouglas A Bell
Nov 19, 2002·Mutagenesis·Simone Benhamou, Alain Sarasin
Feb 5, 2003·Cancer Letters·Tasha R SmithJennifer J Hu
Jan 25, 2005·Breast Cancer Research and Treatment·Priya ChackoM Radhakrishna Pillai
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Nov 11, 2005·Breast Cancer Research : BCR·Katja MetsolaAri Hirvonen
Feb 24, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yawei ZhangMontserrat Garcia-Closas
Sep 12, 2006·Cancer Detection and Prevention·Bharat ThyagarajanMyron D Gross

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Citations

Mar 6, 2010·Breast Cancer Research and Treatment·Li-Xin QiuXi-Chun Hu
Apr 10, 2010·Breast Cancer Research and Treatment·Noel PabalanHilmi Ozcelik
Oct 9, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yulan YanXue Qin
May 19, 2009·The Breast : Official Journal of the European Society of Mastology·Huihua LiBee Choo Tai
Jan 1, 2011·Oncology Letters·Mani SamsonThangarajan Rajkumar

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