Polymorphisms of Toll-Like Receptor 4 as a Risk Factor for Periodontitis: Meta-Analysis

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
Dariusz ChrzęszczykMarek Ziętek

Abstract

Toll-like receptors play an important role in the recognition of periopathogens. There are widely known polymorphisms of these receptors that may alter host susceptibility to periodontitis. Evaluating the association of TLR4 polymorphisms (Asp299 and Thr399Ile) with the occurrence of periodontitis and its two clinical types: chronic (CP) and aggressive (AgP) among Caucasians. A review of 4 electronic databases was made to identify studies that match the inclusion criteria for the meta-analysis and were published up to December 31, 2013. Fifteen studies met the inclusion criteria. For Asp299Gly polymorphism 1621 patients with periodontitis (1148 with CP and 473 with AgP) and 1755 individuals without clinical signs of periodontitis were included in the meta-analysis. The occurrence of polymorphism The 399Ile was evaluated among 1522 patients with periodontitis (1017 with CP and 505 with AgP) and 1461 subjects in the control group. The pooled OR with a random effects model for the Asp299Gly and chronic periodontitis was 1.35 (95% CI: 1.02-1.8, p = 0.038), indicating a possible association between this polymorphism and CP. Other published meta-analyzes showed no significant association between single nucleotide polymorphisms of TLR...Continue Reading

Citations

Oct 19, 2016·Journal of Clinical Periodontology·Luigi NibaliAlexandre R Vieira
Apr 11, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sarah HiyariFlavia Q Pirih
Nov 18, 2018·Journal of Dental Research, Dental Clinics, Dental Prospects·Amir Reza BabalooShima Ghasemi
Aug 6, 2019·Frontiers in Cellular and Infection Microbiology·Lu JiaYi Liu
Jul 10, 2019·Mediators of Inflammation·Joana Maira Valentini ZacariasAna Maria Sell
Nov 24, 2020·Periodontology 2000·Luciana Macchion ShaddoxLuigi Nibali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

© 2022 Meta ULC. All rights reserved