Polymorphisms within the lactoferrin gene promoter in various cattle breeds

Animal Biotechnology
M DalyF Buckley

Abstract

Lactoferrin (Lf) is an iron-binding protein and belongs to the serum transferrin family. It has broad spectrum antimicrobial action, and it is found in exocrine secretions including milk. The sequence of the bovine lactoferrin gene promoter was analyzed in five different cattle breeds (Holstein Friesian, New Zealand Holstein, Montebéliard, Normande, and Norwegian Red) to determine the extent of polymorphic variation, which exists in this region both within and across cattle breeds. Fifteen different single nucleotide polymorphisms (SNPs) were identified throughout this region. Numerous polymorphisms were found throughout the Holstein Friesian, New Zealand Holstein, Montebéliard, and Normande populations. The most frequently encountered polymorphism found in all breeds was at position -28, which is immediately proximal to the TATA box of the promoter. The most variable base position was -131, which included three types of heterozygotes including a single base deletion in one allele, and three homozygote variants. This polymorphism occurs in a putative transcription factor binding site, for the nuclear factor of activated T cells (NF-ATc). A unique polymorphism was identified in one Normande animal, and three polymorphisms were f...Continue Reading

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Citations

Dec 23, 2011·International Journal of Dentistry·João Armando BrancherPaula Cristina Trevilatto
Feb 3, 2015·Polish Journal of Veterinary Sciences·T ZabolewiczS Kamiński
Jan 22, 2019·Reproduction in Domestic Animals = Zuchthygiene·Wael B El-DomanySherif M Nasr
Feb 5, 2008·Journal of Animal Science·A K EsmailizadehW S Pitchford

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

DNASTAR
Chromas
TESS

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