PMID: 198376Oct 1, 1977

Polymorphonuclear leukocyte bactericidal activity and oxidative metabolism during glutathione peroxidase deficiency

Infection and Immunity
D A BassP Szejda

Abstract

Glutathione peroxidase (GPx) deficiency has been proposed as a cause of some instances of chronic granulomatous disease (CGD). GPx activity varies greatly among species, and specific deficiency of this selenium-dependent enzyme can be produced by dietary selenium deficiency in rats. Bactericidal activity of polymorphonuclear (PMN) leukocytes from normal rats, humans, and guinea pigs (GPx high, intermediate, and nearly absent, respectively), selenium-deficient rats (GPx absent), and a patient with CGD were compared. There was no correlation between natural levels of GPx and bactericidal activity; only CGD was associated with inability to kill a Proteus mirabilis strain in vitro (killing known to be dependent on oxidative mechanisms). Postphagocytic metabolism was examined in normal and GPx-deficient rats. Both demonstrated normal iodination and superoxide production during phagocytosis and gave similar histochemical reduction of nitroblue tetrazolium dye under either resting or endotoxin-stimulation conditions. Postphagocytic hexose monophosphate shunt activity was somewhat lower in PMN from GPx-deficient animals as compared with normal but was substantially (10-fold) higher than that observed in resting cells. Thus, postphagocy...Continue Reading

References

Sep 1, 1990·Journal of Dairy Science·J S HoganW L Schockey
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Algirdas J JesaitisZbigniew Lewandowski

Related Concepts

Ovoperoxidase
Neutrophil Band Cells
Selenium
Superoxides
Selenoglutathione Peroxidase
Hexosephosphates
Phagocytosis
Proteus mirabilis
Oxidation-Reduction
Chronic Granulomatous Disease

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