Polymorphous adenocarcinoma of the salivary glands: reappraisal and update

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Vincent Vander PoortenAlfio Ferlito

Abstract

Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG  often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.

References

Jun 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·C M ColmeneroI Sierra
Apr 1, 1991·Oral Surgery, Oral Medicine, and Oral Pathology·J A RegeziR M Courtney
Jan 1, 1991·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·H B Hellquist, M Tytor
Aug 1, 1983·Oral Surgery, Oral Medicine, and Oral Pathology·P D Freedman, H Lumerman
Sep 1, 1983·The Journal of Laryngology and Otology·J G BatsakisG W Tillery
Jun 1, 1995·The Thoracic and Cardiovascular Surgeon·F TanakaY Nakashima
Jan 1, 1994·Oral Surgery, Oral Medicine, and Oral Pathology·S D VincentM W Finkelstein
Dec 1, 1995·The Journal of Laryngology and Otology·K M ThomasJ McEwan
Feb 1, 1996·International Journal of Oral and Maxillofacial Surgery·S J CreanM Harris
Mar 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M SchenkR Hehlmann
Oct 1, 1996·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L NorbergA P Burford-Mason
Jun 11, 1999·American Journal of Clinical Pathology·T J Pelkey, S E Mills
Jul 16, 2002·Archives of Otolaryngology--head & Neck Surgery·K Thomas RobbinsUNKNOWN American Academy of Otolaryngology--Head and Neck Surgery
Sep 20, 2002·American Journal of Otolaryngology·Cory B Pittman, Robert P Zitsch
Nov 8, 2002·Cytopathology : Official Journal of the British Society for Clinical Cytology·Kavita SahaiKusum Verma
Feb 25, 2003·International Journal of Surgical Pathology·Stephanie YoungRajysree Emmadi
Feb 19, 2004·Acta Cytologica·Javier Sáenz-Santamaría, Inmaculada Catalina-Fernandez
Mar 3, 2004·Radiology·Ann D KingAndrew C van Hasselt
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·André Lopes CarvalhoLuiz Paulo Kowalski
Jun 21, 2005·Auris, Nasus, Larynx·Raúl González-GarcíaLuis Naval-Gías
Oct 13, 2005·Virchows Archiv : an International Journal of Pathology·Sofia AsioliVincenzo Eusebi
Feb 21, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·David BeltranMeredith August
Sep 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Allen M ChenKaren K Fu
Dec 6, 2006·The Laryngoscope·Matthew S PogodzinskiKerry D Olsen
Jan 20, 2007·Seminars in Ultrasound, CT, and MR·Gitta Madani, Timothy Beale
Mar 30, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Amos BuchnerWilliam M Carpenter
Jul 20, 2007·Diagnostic Cytopathology·Umesh Kapur, Eva M Wojcik
Oct 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Chris H J Terhaard
Oct 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Misa SumiTakashi Nakamura
Dec 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Manju L PrasadPing Wen
Mar 11, 2008·Current Opinion in Otolaryngology & Head and Neck Surgery·Vinidh PaleriPatrick Bradley
Jul 12, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Viboon BoonsarngsukPiemsak Prakardvudhisarn
Oct 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marta PerssonGöran Stenman
Apr 21, 2010·Archives of Otolaryngology--head & Neck Surgery·Raja R SeethalaEugene N Myers
Jun 29, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Giuseppe ColellaMaria P Foschini
Feb 4, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Imad Abu El-NaajMicha Peled

❮ Previous
Next ❯

Citations

Jul 5, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Aanchal KakkarVenkateswaran K Iyer
Jul 18, 2019·Insights Into Imaging·Nisa OrenDaniel T Ginat
Oct 8, 2020·Der Radiologe·R RotzingerF Ahlhelm
Jan 4, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alyssa M CivantosKarthik Rajasekaran
Oct 24, 2019·Cancer Treatment Reviews·Gerben LasscheCarla M L van Herpen
Jan 6, 2021·Head and Neck Pathology·Kiyohiko SakataMotohiro Morioka
Dec 29, 2020·Histopathology·Juan C Hernandez-PreraBruce M Wenig
Apr 19, 2021·European Journal of Radiology·Davide MaraghelliStefano Colagrande
Apr 21, 2021·Neoplasia : an International Journal for Oncology Research·Sandra N FreibergerNiels J Rupp
Aug 5, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Paul E Wakely, Abberly A Lott-Limbach
Sep 18, 2021·BMJ Case Reports·Priya K NairMahija Janardhanan
Mar 17, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Eduardo Morato de OliveiraMaria Cássia Ferreira de Aguiar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.