Polymorphous light eruption (PLE) and a new potent antioxidant and UVA-protective formulation as prophylaxis

Photodermatology, Photoimmunology & Photomedicine
I HadshiewF Rippke

Abstract

Polymorphous light eruption (PLE) is the most common photodermatosis. While its etiology still remains elusive, pathogenesis seems to involve UVA-induced oxidative stress and subsequent deregulation of antioxidative immune responses. Only few and often ineffective prophylactic and therapeutic measures exist to date. In our randomized, double-blind, placebo-controlled clinical study, we compared the efficacy of a new topical formulation, consisting of 0.25%alpha-glucosylrutin (AGR) (a natural, modified flavonoid), 1% tocopheryl acetate (vitamin E) and a broad-spectrum, highly UVA-protective sunscreen (SPF 15) in a hydrodispersion gel vehicle, to a sunscreen-only gel and vehicle. Thirty patients with a history of PLE were pretreated with either the above formulation, a similar preparation (with the same concentration for vitamin E and AGR, but a different UV filter system), placebo or a SPF 15 sunscreen-only gel, 30 min prior to daily photoprovocation with UVA irradiations of 60-100 J/cm(2) to 5 x 5 cm(2) areas on the upper arms. After 4 days, results revealed a statistically highly significant difference (P<0.001) between the antioxidant containing formulations and placebo, and sunscreen-only formulation, respectively, in experi...Continue Reading

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Citations

Mar 18, 2006·Photochemistry and Photobiology·Patrícia M B G Maia CamposLorena R Gaspar
Jun 24, 2011·Journal of the American Academy of Dermatology·Adrian TanewPiergiacomo Calzavara-Pinton
Nov 12, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Rainer WolberKlaus-Peter Wittern
Aug 23, 2007·The British Journal of Dermatology·M Yaar, B A Gilchrest
Jan 10, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·M ZirbsB Eberlein
Nov 29, 2005·Dermatologic Clinics·Vincent Deleo
Jul 1, 2018·American Journal of Clinical Dermatology·Amanda F NahhasHenry W Lim

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