Polymyalgia rheumatica in a melanoma patient 11 months after completion of immunotherapy with nivolumab.

Cancer Reports
Yolanka LoboFelicity Murphy

Abstract

Immune checkpoint inhibitor (ICI) therapy has revolutionised the treatment of several cancers but can also lead to the development of immune-related adverse effects including dermatologic, gastrointestinal, endocrine, hepatic, pulmonary and less commonly, rheumatic toxicities. Toxicities associated with ICI therapy can occur several months or even years after initiation. Case reports of polymyalgia rheumatica (PMR) associated with nivolumab use are rare. We herein describe, for the first time, a case of PMR in a melanoma patient after cessation of treatment with nivolumab. An 88-year-old man with a history of stage IV M1c BRAF wild-type melanoma presented with a 1 month history of arthralgias and morning stiffness, predominantly affecting the shoulders and hips, associated with fatigue and weight loss. He had undergone wide local excision of a primary malignant melanoma in the left buttock region several years prior. Immunotherapy with nivolumab was initiated following disease relapse with multiple metastases. Nivolumab was discontinued due to demonstration of complete metabolic response on serial positron emission and computed tomography scans. Symptoms appeared 11 months after completion of treatment. A diagnosis of PMR was m...Continue Reading

References

Oct 1, 1979·Annals of the Rheumatic Diseases·H A BirdP H Wood
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jan 15, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M MichotO Lambotte
Mar 8, 2017·Journal of Immunotherapy·Marjorie BernierMarion Sassier
May 19, 2017·Journal of Cancer Research and Clinical Oncology·Kiyotaka NakamagoeAkira Tamaoka
Jun 11, 2017·Annals of the Rheumatic Diseases·Rakiba BelkhirXavier Mariette
Dec 2, 2017·Seminars in Arthritis and Rheumatism·Wilson F KuswantoBonnie L Bermas
Feb 15, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerUNKNOWN National Comprehensive Cancer Network
Feb 26, 2019·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Albrecht Betrains, Daniel Engelbert Blockmans
Mar 5, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yusuke ImaiKazuichi Okazaki

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