Polymyositis in African HIV-infected subjects

Neuromuscular Disorders : NMD
Jeannine M HeckmannC Kenyon

Abstract

Polymyositis in HIV-infected subjects, clinically and pathologically resemble polymyositis in non-HIV-infected subjects. We report 14 consecutive HIV-associated polymyositis cases and compare specific features with 25 polymyositis cases seen over the same 6.5 year period. The HIV-polymyositis cases were all female and compared to the polymyositis cases were younger (median age 33 years, interquartile range (IQR) 29; 37 vs. 46 years, IQR 38; 52, p=0.002), and with 4-fold lower serum creatine kinase (CK) values (median 1158 vs. 5153IU/l; p=0.019). A definite clinical improvement on prednisone therapy was documented in eight HIV-polymyositis cases and one improved with anti-retroviral therapy alone. The recognition of HIV-polymyositis which is treatable, but may present with serum CK elevations less than twofolds above normal, is clinically relevant in sub-Saharan Africa where electromyography and muscle biopsies are not readily available.

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Citations

Mar 1, 2012·Journal of Clinical Neuromuscular Disease·Taylor B Harrison, Bryan Smith
Dec 31, 2011·Journal of Neurovirology·Jessica Robinson-PappDavid M Simpson
Feb 5, 2016·Journal of Neuropathology and Experimental Neurology·Annie HinikerMarta Margeta
Mar 7, 2015·Internal Medicine·Yu KakuMasahiro Yamamoto
Jan 26, 2017·Medicine·Emilie VirotPascal Seve

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