PMID: 15253079Jul 16, 2004Paper

Polymyxin B protects horses against induced endotoxaemia in vivo

Equine Veterinary Journal
M H BartonN Norton

Abstract

A safe, affordable and effective treatment for endotoxaemia in horses is needed in order to reduce the incidence of this potentially fatal condition. To evaluate the effect of polymyxin B (PMB) on signs of experimentally-induced endotoxaemia. PMB ameliorates the adverse effects of endotoxaemia without causing nephrotoxicity. Four groups of 6 healthy mature horses each received 20 ng endotoxin/kg bwt i.v. over 30 mins. Additionally, each group received one of the following i.v.; 5000 u PMB/kg bwt 30 mins before endotoxin infusion; 5000 u PMB/kg bwt 30 mins after endotoxin infusion; 1000 u PMB/kg bwt 30 mins prior to endotoxin infusion; or saline. Clinical response data and samples were collected to determine neutrophil count, serum tumour necrosis factor (TNF) activity, plasma thromboxane B2 concentration and urine gamma glutamyltranspeptidase (GGT) to creatinine ratio. Treatment with PMB before or after administration of endotoxin significantly reduced fever, tachycardia and serum TNF, compared to horses receiving saline. The differences in response to endotoxin were greatest between horses that received saline vs. those that received 5000 u PMB/kg bwt prior to endotoxin. Urine GGT:creatinine did not change significantly. This ...Continue Reading

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Citations

Jan 3, 2008·American Journal of Veterinary Research·Ferenc TóthRaymond C Boston
Sep 2, 2011·American Journal of Veterinary Research·Chad A BaumwartBarton W Rohrbach
Jul 28, 2016·Journal of Veterinary Pharmacology and Therapeutics·A H Werners
Aug 15, 2017·Journal of Veterinary Pharmacology and Therapeutics·J R BauquierS R Bailey
Feb 1, 2015·Equine Veterinary Education·S Taylor
Apr 4, 2006·American Journal of Veterinary Research·Peter R Morresey, Robert J Mackay
Mar 22, 2008·Equine Veterinary Journal·G KelmerF M Andrews
Jul 24, 2010·Journal of Veterinary Internal Medicine·J R PeiróC A A Valadão
Sep 6, 2013·Journal of the American Veterinary Medical Association·David M WongWalter H Hsu
Oct 20, 2012·Journal of the American Veterinary Medical Association·Laura C NathCatherine J Savage
Jul 3, 2008·American Journal of Veterinary Research·Amy E Poulin BraimShri N Giri
Aug 29, 2012·American Journal of Veterinary Research·Elizabeth M Tadros, Nicholas Frank
Jul 21, 2005·Equine Veterinary Journal·A H WernersJ Fink-Gremmels
Feb 17, 2010·Journal of Feline Medicine and Surgery·Claire R SharpCarol R Reinero
May 29, 2020·Journal of Veterinary Internal Medicine·Francisco Javier Mendoza GarciaAlejandro Perez-Ecija
Jul 13, 2011·Journal of Veterinary Internal Medicine·C J AlcottW Hsu
Mar 23, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Luciane Dias de OliveiraMarcia Carneiro Valera
Feb 11, 2021·Equine Veterinary Journal·Cajsa M IsgrenGina L Pinchbeck
Jul 4, 2013·Veterinary Immunology and Immunopathology·S KwonM L Vandenplas
Mar 23, 2011·Veterinary Immunology and Immunopathology·Vanessa L CookLorraine M Sordillo

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