Polymyxins: Mode of Action

Advances in Experimental Medicine and Biology
Zhifeng Li, Tony Velkov

Abstract

The dry antibiotic development pipeline coupled with the emergence of multi-drug resistant Gram-negative 'superbugs' has driven the revival of the polymyxin lipopeptide antibiotics. Understanding the mode of action of antibiotics is an important precursor for optimizing their use and development. This chapter provides a concise treatise of the current knowledge-based on the primary mode of action of polymyxins as well as recent developments in understanding of bacterial cell responses and secondary modes of action.

Citations

Aug 19, 2020·Expert Opinion on Therapeutic Patents·Claudiu T Supuran, Clemente Capasso
Sep 30, 2020·The Journal of Antimicrobial Chemotherapy·Cristina F MallaMaría M Tavío
Feb 23, 2021·ACS Applied Materials & Interfaces·Xingyue YangYumiao Zhang
Feb 5, 2021·Clinical Pharmacology and Therapeutics·Kevin J Downes, Jennifer L Goldman
Jun 3, 2021·Nature Reviews. Microbiology·Simon HeilbronnerAndreas Peschel
Aug 18, 2021·Expert Opinion on Pharmacotherapy·Daniele Roberto GiacobbeMatteo Bassetti

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