Poly(N-isopropylacrylamide-co-acrylamide) cross-linked thermoresponsive microspheres obtained from preformed polymers: Influence of the physico-chemical characteristics of drugs on their release profiles

Acta Biomaterialia
G FundueanuPaolo Ascenzi

Abstract

Poly(N-isopropylacrylamide-co-acrylamide) copolymer was synthesized as an interesting thermoresponsive material possessing a phase transition temperature of around 36 degrees C in phosphate buffer, pH 7.4 (PB); the concentration was 10%, w/v. The copolymer maintains a sharp phase transition at a relatively high percentage of acrylamide. The lower critical solution temperature (LCST) of the copolymer is influenced by the concentration of copolymer solution in PB. The copolymer was transformed in thermoresponsive microspheres by chemical cross-linking of amide groups with glutaraldehyde. The key factors for the successful preparation of microspheres are the use of a concentrated polymer solution, a temperature (38 degrees C) that is high enough but lower than LCST, and a long reaction time (48h). The microspheres were characterized by optical and scanning electron microscopy, swelling/deswelling kinetics, swelling degree, and PB retention at different temperatures. Finally, the influence of hydrophilicity/hydrophobicity and the molecular weight of the drugs (propranolol, lidocaine, vitamin B(12)) on their release profile from thermoresponsive microspheres were examined. Above LCST the hydrogel matrix is in the dehydrated state an...Continue Reading

Citations

Apr 9, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gheorghe FundueanuBogdan C Simionescu
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May 23, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marieta ConstantinGheorghe Fundueanu
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Jun 10, 2009·International Journal of Pharmaceutics·Gheorghe FundueanuPaolo Ascenzi
Nov 28, 2012·Journal of Biomedical Materials Research. Part a·Gheorghe FundueanuBogdan C Simionescu
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Dec 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Faisal KhanShahab A A Nami

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