Poly(N-isopropylacrylamide)-gated Fe3O4/SiO2 core shell nanoparticles with expanded mesoporous structures for the temperature triggered release of lysozyme

Colloids and Surfaces. B, Biointerfaces
Erick YuPedro Amorós

Abstract

Core-shell nanoparticles comprised of Fe3O4 cores and a mesoporous silica shell with an average expanded pore size of 6.07 nm and coated with a poly(N-isopropylacrylamide) (PNIPAM) layer (CS-MSNs-EP-PNIPAM) were prepared and characterized. The nanoparticles was loaded with (Ru(bipy)3(2+)) dye or an antibacterial enzyme, lysozyme, to obtain CS-MSNs-EP-PNIPAM-Ru(bipy)3(2+) and CS-MSNs-EP-PNIPAM-Lys, respectively. The lysozyme loading was determined to be 160 mg/g of nanoparticle. It was seen that Ru(bipy)3(2+) and lysozyme release was minimal at a room temperature of 25 °C while at physiological temperature (37 °C), abrupt release was observed. The applicability of the CS-MSNs-EP-PNIPAM-Lys was further tested with two Gram-positive bacteria samples, Bacillus cereus and Micrococcus luteus. At physiological temperature, the nanoparticles were shown to reduce bacterial growth, indicating a successful release of lysozyme from the nanoparticles. This nanoparticle system shows potential as a nanocarrier for the loading of similarly sized proteins or other species as a drug delivery platform.

References

Oct 10, 2002·Chemical Reviews·A P Wight, M E Davis
May 26, 2004·Journal of Colloid and Interface Science·Ivan Sondi, Branka Salopek-Sondi
Jun 17, 2004·Angewandte Chemie·Guido Kickelbick
Jul 3, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·N NitinG Bao
Jun 26, 2007·Journal of the American Chemical Society·Igor I SlowingVictor S-Y Lin
Aug 30, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andrea BernardosJuan Soto
May 1, 2009·Journal of the American Chemical Society·Elena AznarCarmen Guillem
Jun 13, 2009·Expert Opinion on Drug Delivery·Elena AznarFélix Sancenón
Aug 20, 2010·Journal of the American Chemical Society·Huan MengAndre E Nel
Aug 26, 2010·Angewandte Chemie·Estela ClimentPedro Amorós
Jan 22, 2011·ACS Nano·Eduardo Ruiz-HernándezMaría Vallet-Regí
Apr 6, 2011·Advanced Drug Delivery Reviews·Mihaela DelceaAndré G Skirtach
Jun 22, 2011·Journal of Colloid and Interface Science·Jixi ZhangHong-chen Gu
Oct 28, 2011·Expert Review of Anti-infective Therapy·Adil M AllahverdiyevMiriam Rafailovich
Feb 7, 2012·Journal of the American Chemical Society·Meng-Hua XiongJun Wang
Mar 24, 2012·Chemical Society Reviews·Piaoping YangJun Lin
Jul 26, 2012·Environmental Science & Technology·Stephen KrollKurosch Rezwan
Aug 2, 2012·ACS Applied Materials & Interfaces·Mi Mi WanJian Hua Zhu
Dec 12, 2012·Accounts of Chemical Research·Carmen CollFélix Sancenón
Jun 12, 2013·Chemical Communications : Chem Comm·Elena AznarPedro Amorós
Feb 13, 2014·Chemical Communications : Chem Comm·Cristina de la TorreEnríque Pérez-Payá
Feb 21, 2014·Chemical Communications : Chem Comm·Zhengze YuBo Tang
Apr 9, 2014·ACS Applied Materials & Interfaces·Carolina AcostaRámon Martínez-Máñez
Jun 12, 2014·Microbiological Research·Michał ArabskiWiesław Kaca

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Citations

Jun 14, 2016·Colloids and Surfaces. B, Biointerfaces·Baolin WangJing-Song Li
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Juan WuRenbing Tian
Feb 22, 2017·Chemistry : a European Journal·Antoni Llopis-LorenteReynaldo Villalonga
Jul 7, 2018·Journal of Food Science·María Ruiz-RicoJosé M Barat
Aug 9, 2019·Chemical Communications : Chem Comm·Tian DengJeffrey I Zink
May 26, 2020·Advanced Healthcare Materials·María Vallet-RegíIsabel Izquierdo-Barba
Sep 8, 2020·Advanced Healthcare Materials·Danyang LiJulien E Gautrot
Dec 2, 2017·Chemistry : a European Journal·Cristina de la TorreFélix Sancenón
Apr 30, 2019·Small·Andrea BernardosRamón Martínez-Máñez
Aug 8, 2020·Frontiers in Chemistry·Vanitha SelvarajanPui Lai Rachel Ee
Oct 23, 2020·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Saeed KamaliPieter Stroeve
Nov 19, 2020·International Journal of Molecular Sciences·Montserrat Colilla, María Vallet-Regí
Nov 25, 2020·Journal of Physics. Condensed Matter : an Institute of Physics Journal·S KamaliP Stroeve
Oct 15, 2019·ACS Applied Materials & Interfaces·Ahmed F HalbusVesselin N Paunov
Oct 11, 2021·International Journal of Pharmaceutics·Dnyaneshwar KalyaneRakesh Kumar Tekade

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