Polynocturia in chronic kidney disease is related to natriuresis rather than to water diuresis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Michio FukudaGenjiro Kimura

Abstract

Nocturnal polyuria has been well known in renal insufficiency. Recently, we found that as renal function deteriorated in chronic kidney disease (CKD), natriuresis was enhanced during the night with nocturnal blood pressure elevation. In the present study, we investigated whether nocturnal polyuria in CKD was due to the inability to concentrate urine, as previously proposed, or based on osmotic diuresis mainly by natriuresis. In 27 CKD patients, circadian rhythms of urinary sodium, potassium, urea and osmolar excretion rates (U(Na)V, U(K)V, U(urea)V, U(osm)V) as well as of urinary volume (V) and free-water clearance (C(H(2)O)) were estimated during both daytime (6:00 to 21:00) and nighttime (21:00 to 6:00). Then, the night/day ratios of these parameters were analysed in relation to creatinine clearance (C(cr)) as a marker of glomerular filtration rate. C(cr) had significantly negative relationships with night/day ratios of V (R = -0.69; P < 0.0001), U(osm)V (R = -0.54; P = 0.004) and U(Na)V (R = -0.63; P = 0.0005), but no correlation with night/day ratios of C(H(2)O) (R = -0.33; P = 0.1), U(K)V (R = -0.29; P = 0.1) or U(urea)V (R = -0.31; P = 0.1). Linear and multiple regression analysis identified nocturnal natriuresis rather t...Continue Reading

References

Sep 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D A Feinfeld, G M Danovitch
Feb 1, 1996·Journal of the American Society of Nephrology : JASN·B CianciarusoL De Nicola
Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T FujiiG Kimura
May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lee A HebertSaulo Klahr
Sep 6, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Norihiko GotoGenjiro Kimura

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Citations

Feb 25, 2009·Archives of Internal Medicine·Chi-yuan HsuAlan S Go
Nov 5, 2011·International Urogynecology Journal·Daniele FurtadoSergio Tufik
Feb 3, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Amira Peco-AntićDusan Paripović
Apr 10, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Genjiro KimuraMichio Fukuda
Jan 25, 2012·American Journal of Nephrology·Lesley GardinerAlan R Parrish
Jul 9, 2010·Advances in Chronic Kidney Disease·Sarinya BoongirdMark L Unruh
Sep 18, 2007·Seminars in Nephrology·Michel BurnierMurielle Bochud
Mar 21, 2008·BJU International·Marian J A Van der WeideLukas B Hilbrands
Jun 9, 2006·Medical Hypotheses·Michio FukudaGenjiro Kimura
May 15, 2015·Annual Review of Nutrition·Mary E CogswellBarbara A Bowman
Feb 8, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yoshiaki OgiyamaGenjiro Kimura
Jun 4, 2010·American Journal of Physiology. Renal Physiology·Konstantinos KamperisJens Christian Djurhuus
Mar 25, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Massimo CirilloMartino Laurenzi
Jan 16, 2016·Clinical and Experimental Nephrology·Daniela Lemos BorgesSebastião Rodrigues Ferreira Filho

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