Polyol-pathway-dependent disturbances in renal medullary metabolism in experimental insulin-deficient diabetes mellitus in rats

Diabetologia
Fredrik PalmP-O Carlsson

Abstract

The renal medullary region is particularly vulnerable to reduced oxygen concentration because of its low blood perfusion and high basal oxygen consumption. This study investigated renal metabolic changes in relation to the previously observed decreased oxygen tension in streptozotocin-induced diabetic rats. Blood perfusion, oxygen tension and consumption, interstitial pH, and glycolytic and purine-based metabolites were determined in the renal cortex and the medulla of non-diabetic and diabetic animals by, respectively, laser Doppler flowmetry, oxygen and pH microelectrodes, and microdialysis. The importance of increased polyol pathway activity for the observed alterations was investigated by daily treatment with the aldose reductase inhibitor AL-1576 throughout the course of diabetes. The diabetes-induced decrease in renal oxygen tension, due to augmented oxygen consumption, did not result in manifest hypoxia in either the cortical or the medullary region, as evaluated by microdialysis measurements of purine-based metabolites. The profound alterations in medullary oxygen metabolism were, however, associated with an increased lactate : pyruvate ratio and a concomitantly decreased pH. Notably, the renal medullary changes in oxyg...Continue Reading

References

May 1, 1987·Metabolism: Clinical and Experimental·B W GriffinB M York
Jan 1, 1985·Advances in Experimental Medicine and Biology·P J DyckB Zimmerman
Oct 1, 1984·Kidney International·M BrezisF H Epstein
Mar 9, 1995·The New England Journal of Medicine·M Brezis, S Rosen
Jun 1, 1994·Journal of the American Society of Nephrology : JASN·J L Logan, U F Michael
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Jun 1, 1993·Diabetes·J R WilliamsonR G Tilton
Jan 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G Wolf, F N Ziyadeh
Nov 5, 1997·Kidney International·J MelinB C Fellström
Nov 18, 1998·Current Opinion in Nephrology and Hypertension·M MurphyC Godson
Jun 3, 1999·Kidney International·A KoivistoA E Persson
Feb 1, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·T ThomasJ B Watkins
Sep 21, 2000·Kidney International. Supplement·T NishikawaM Brownlee
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·John HaylorA Meguid El Nahas
Jul 12, 2002·American Journal of Physiology. Renal Physiology·Andrew Baines, Patrick Ho
Aug 9, 2002·Upsala Journal of Medical Sciences·F PalmP O Carlsson
Nov 7, 2002·American Journal of Physiology. Endocrinology and Metabolism·Per-Ola CarlssonFredrik Palm
Jan 1, 1951·Acta Medica Scandinavica·P HORSTMANN

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Citations

Nov 28, 2012·Clinical and Experimental Pharmacology & Physiology·Peter HansellFredrik Palm
Jan 31, 2013·Clinical and Experimental Pharmacology & Physiology·Prabhleen SinghLina Nordquist
Sep 28, 2006·Clinical and Experimental Pharmacology & Physiology·Fredrik Palm
May 4, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrik PerssonFredrik Palm
Apr 8, 2006·American Journal of Physiology. Renal Physiology·Pottumarthi V Prasad
Nov 20, 2009·American Journal of Physiology. Renal Physiology·Fredrik PalmOrjan Källskog
Dec 19, 2013·BioMed Research International·Samuel N HeymanMogher Khamaisi
Nov 20, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christoffer LaustsenHans Stødkilde Jørgensen
Aug 28, 2010·Hemodialysis International·Maryam PakfetratParviz Khajehdehi
Nov 21, 2012·Diabetes/metabolism Research and Reviews·Christoffer LaustsenJan Henrik Ardenkjaer-Larsen
May 18, 2005·The International Journal of Biochemistry & Cell Biology·Fredrik Palm, Per-Ola Carlsson
Mar 1, 2012·Metabolism: Clinical and Experimental·Nicole StiegerMario Schiffer
May 14, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lotte B BertelsenChristoffer Laustsen
Jun 29, 2016·Diabetes Research and Clinical Practice·Yan-Ming TianYi Zhang
Apr 18, 2015·PloS One·Ju CuiJian-Dong Huang
Mar 22, 2016·Physiological Reports·Haiyun QiChristoffer Laustsen
Apr 19, 2018·American Journal of Physiology. Renal Physiology·Sofia JönssonMichael Hultström
Jan 25, 2018·American Journal of Physiology. Renal Physiology·Anita T Layton, Volker Vallon
Feb 13, 2008·Nature Clinical Practice. Nephrology·Dhruv K SinghKen Farrington
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Apr 9, 2009·Nature Reviews. Endocrinology·Dhruv K SinghKen Farrington
Mar 10, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Haiyun QiChristoffer Laustsen
Apr 11, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shai EfratiJoshua Weissgarten
Dec 20, 2007·Current Opinion in Nephrology and Hypertension·Prabhleen SinghRoland C Blantz
Sep 4, 2014·Journal of the American Society of Nephrology : JASN·Lina NordquistFredrik Palm
Jul 24, 2014·BioMed Research International·Yumi Takiyama, Masakazu Haneda
Apr 10, 2015·American Journal of Physiology. Renal Physiology·Anita T LaytonAurélie Edwards
Jan 31, 2020·Physiological Reviews·Jens Leipziger, Helle Praetorius
Jan 11, 2017·American Journal of Physiology. Renal Physiology·Christoffer LaustsenHans Stødkilde-Jørgensen
Jul 14, 2017·Frontiers in Physiology·Zhi Zhao LiuPrabhleen Singh
Jan 15, 2016·American Journal of Physiology. Renal Physiology·Anita T LaytonAurélie Edwards
Mar 25, 2017·Physiological Reports·Thomas S NørlingerChristoffer Laustsen
Jun 30, 2018·Biological cybernetics·Anita T Layton

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