Polyoma virus-associated carcinomas of the urologic tract: a clinicopathologic and molecular study

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Deepika SirohiDaniel J Luthringer

Abstract

In recent years, there has been increased interest in carcinomas of the urologic tract, that demonstrate association with the polyoma virus BK arising in immunosuppressed individuals, though the nature of this association is uncertain. To begin to understand this phenomenon, we reviewed the clinical, morphological, and immunohistochemical features of 11 carcinomas of the urologic tract, mainly urothelial (N = 9) and collecting duct carcinomas (N = 2), occurring during immunosuppression, and expressing polyoma virus T-antigen by immunohistochemistry. These were compared to a control group of carcinomas (N = 8), also arising during immunosuppression, but without T-antigen expression. A subset of both groups were also studied by hybrid capture-based DNA sequencing, probing not only for 479 cancer-related human genes, but also for polyoma and other viral sequences. Polyoma T-antigen-expressing tumors arose in 7 males and 4 females, at a median age of 66, and were aggressive, high-grade tumors with more than 1 variant morphologic pattern identified in 81% of cases, and a majority (73%) presenting at high stage category (>pT3). Diffuse polyoma T-antigen staining was seen in 91% of cases, with co-localization of aberrant p53 staining ...Continue Reading

References

Dec 1, 1973·The Journal of Infectious Diseases·K V ShahR M Warszawski
Feb 17, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anders S Y WongAnskar Y H Leung
Feb 5, 2008·Cell Cycle·William Y Tsang, Brian David Dynlacht
Dec 23, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Javid GazievGuido Lucarelli
Jan 19, 2010·Bioinformatics·Heng Li, Richard Durbin
Oct 5, 2010·Diagnostic Cytopathology·Sanam Loghavi, Shikha Bose
Apr 5, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C C GeddesW F Carman
Nov 3, 2011·JAMA : the Journal of the American Medical Association·Eric A EngelsMonica Lin
Jan 17, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Stephanie DufekChristoph Aufricht
Apr 5, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S BialasiewiczN Isbel
Oct 10, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J Y Z LiJ M Gleadle
Oct 15, 2013·The Journal of Infection·Michelle Pinto, Simon Dobson
Feb 28, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Deirdre Sawinski, Simin Goral
Nov 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Morassa MohseniBen Ho Park
Mar 4, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F FaveroC Swanton
Jul 15, 2015·The Journal of Pathology·Daniel J KenanVolker Nickeleit
Jan 6, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C PapadimitriouH H Hirsch
Jan 1, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D J KenanV Nickeleit

❮ Previous
Next ❯

Citations

Oct 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sara QueridoDomingos Machado
Feb 13, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Simone BertzAntje Knöll
May 10, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Alyson PromSandesh Parajuli
Sep 16, 2020·Virology Journal·Yigang ZengTongyu Zhu
Jul 25, 2019·Current Opinion in Virology·Gabriel J Starrett, Christopher B Buck
Feb 25, 2020·Transplantation·Raphael P H MeierThierry Berney
Mar 6, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kiril TrpkovAnthony J Gill
Mar 25, 2019·Kidney International·Geetika SinghDipankar Bhowmik

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
electron microscopy
PCR

Software Mentioned

superDeDuper
BamBam
Integrated Genome Viewer
Basic Local Alignment Search Tool ( BLAST )
bwa
Integrative Genomics Viewer ( IGV
Surpi
MAFFT
GATK

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.