Abstract
Polyoma (BK) virus-type cellular changes are occasionally reported in urine specimens, yet rarely detected in histologic sections of bladder biopsies. A total of 762 predominantly voided urine specimens with a cytologic diagnosis of polyoma virus-type change were retrieved from the cytopathology files of the Johns Hopkins Hospital over a 15-year period (1988-2003). Biopsies were available for 33 cases (29 patients) following or preceding the urinary cytology (mean interval, 210 days). The biopsies originated primarily from bladder (n=31) with one biopsy each from renal pelvis and urethra. Representative paraffin blocks were chosen from each case for immunoperoxidase staining with SV40 large T antigen. There were 22 males and 7 females with an age range of 34 to 79 years (mean, 64.7 years). The histologic diagnoses of the 33 tissue biopsies were: benign urothelium (n=9), urothelial carcinoma (n=21) and 1 case each of dysplasia, small cell carcinoma, and chronic lymphocytic leukemia involving lamina propria of the bladder. Only 3 of 33 biopsies on hematoxylin-stained sections showed morphologic changes of polyoma virus, which lacked sufficient tissue to perform immunohistochemistry for SV40 large T antigen (LTag). Immunohistochem...Continue Reading
Citations
Nov 4, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Volker Nickeleit, Michael J Mihatsch
Jul 12, 2008·Diagnostic Cytopathology·Guoping Cai, Anil V Parwani
Nov 22, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C E TsengM Wang
Oct 5, 2010·Diagnostic Cytopathology·Sanam Loghavi, Shikha Bose
Dec 2, 2015·Diagnostic Cytopathology·Sule CanberkFernando Schmitt
Jun 1, 2009·NDT Plus·Prue HillDavid Goodman
Oct 18, 2014·Cytopathology : Official Journal of the British Society for Clinical Cytology·S AriyasuK Takahashi
Jun 29, 2011·Diagnostic Cytopathology·S A Thiryayi, D N Rana
Oct 20, 2020·Frontiers in Immunology·Yang HuangGang Huang
Dec 12, 2020·Viruses·Faisal KlufahIryna V Samarska
Jun 10, 2009·Seminars in Cancer Biology·Johanna R AbendMichael J Imperiale
Dec 1, 2008·Surgical Pathology Clinics·Joshua F Coleman, Donna E Hansel