Polyoma virus-induced osteosarcomas in inbred strains of mice: host determinants of metastasis.

PLoS Pathogens
Palanivel VelupillaiThomas Benjamin

Abstract

The mouse polyoma virus induces a broad array of solid tumors in mice of many inbred strains. In most strains tumors grow rapidly but fail to metastasize. An exception has been found in the Czech-II/Ei mouse in which bone tumors metastasize regularly to the lung. These tumors resemble human osteosarcoma in their propensity for pulmonary metastasis. Cell lines established from these metastatic tumors have been compared with ones from non-metastatic osteosarcomas arising in C3H/BiDa mice. Osteopontin, a chemokine implicated in migration and metastasis, is known to be transcriptionally induced by the viral middle T antigen. Czech-II/Ei and C3H/BiDa tumor cells expressed middle T and secreted osteopontin at comparable levels as the major chemoattractant. The tumor cell lines migrated equally well in response to recombinant osteopontin as the sole attractant. An important difference emerged in assays for invasion in which tumor cells from Czech-II/Ei mice were able to invade across an extracellular matrix barrier while those from C3H/BiDa mice were unable to invade. Invasive behavior was linked to elevated levels of the metalloproteinase MMP-2 and of the transcription factor NFAT. Inhibition of either MMP-2 or NFAT inhibited invasio...Continue Reading

References

May 1, 1977·American Journal of Clinical Pathology·G Uribe-BoteroR G Martin
Dec 1, 1995·Journal of Virology·P H BauerT L Benjamin
Jan 1, 1994·Current Biology : CB·T JacksR A Weinberg
Dec 1, 1993·Molecular and Cellular Biology·J A LeesK Helin
Oct 1, 1996·Seminars in Cancer Biology·A BilgerW F Dove
Jan 1, 1997·Annual Review of Immunology·A RaoP G Hogan
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·R BronsonT Benjamin
Dec 6, 1997·Biochemical and Biophysical Research Communications·S PanK Arai
May 22, 1998·Trends in Genetics : TIG·A Balmain, H Nagase
Jun 18, 2002·Clinical & Experimental Metastasis·Gianluigi GiannelliAdriana Albini
Jun 25, 2002·Nature Cell Biology·Sebastien JauliacAlex Toker
Sep 5, 2002·Journal of Virology·Palanivel VelupillaiThomas L Benjamin
Aug 28, 2003·The EMBO Journal·Billy TsaiTom A Rapoport
Apr 16, 2004·Breast Cancer Research : BCR·Katayoun Alavi JessenJeffrey P Gregg
Sep 7, 2004·The International Journal of Developmental Biology·Adriana AlbiniClaudio Brigati
Sep 29, 2005·Journal of Virology·Jean DahlThomas L Benjamin
Mar 14, 2008·Current Opinion in Genetics & Development·Tim Molloy, Laura J van 't Veer
Aug 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Seth D BermanJacqueline A Lees

❮ Previous
Next ❯

Citations

Sep 13, 2012·Journal of Osteoporosis·Elena AdinolfiAnna Lisa Giuliani
Feb 24, 2011·Veterinary Pathology·A M KavirayaniO Foreman
Aug 20, 2010·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Alexander KönigVolker Ellenrieder
Jul 30, 2014·Biochimica Et Biophysica Acta·Jiang-Jiang QinRuiwen Zhang
Feb 1, 2017·Vascular Pharmacology·Rosalinda MadonnaRaffaele De Caterina
Dec 18, 2014·Medical Oncology·Yu-Sheng LiGuang-Hua Lei
Mar 12, 2019·Oncology Letters·Xingwen HanXun Li
Dec 6, 2018·Journal of Cellular Physiology·Sonia VillaniSerena Delbue
Jul 31, 2019·Experimental and Molecular Pathology·Xi LiuZhi-Qiang Luo
May 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhicheng YaoMeihai Deng
Jul 9, 2021·Journal of Bone Oncology·Ali NazarizadehMasoumeh Tavakoli-Yaraki

❮ Previous
Next ❯

Datasets Mentioned

BETA
O88942

Methods Mentioned

BETA
transgenic
electrophoresis
transfection
ELISA

Software Mentioned

LI
COR Odyssey

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.