Polyoma virus nephropathy in kidney transplantation

World Journal of Transplantation
Jacob Rw ScaddenRichard Borrows

Abstract

BK virus (BKV) is a polyomavirus that is able to cause renal dysfunction in transplanted grafts via BK virus-associated nephritis (BKVAN). This condition was mis-diagnosed in the past due to clinical and histopthological similarities with acute rejection. Due to the prevalence of the virus in the population, it is an important pathogen in this context, and so it is important to understand how this virus functions and its' relationship with the pathogenesis of BKVN. Screening for BKV often reveals viruria and/or viremia, which then manifests as BKVN, which can be asymptomatic or result in clinical features namely renal dysfunction. The pathogenesis of BKV infection is still unclear and needs to be further investigated; nevertheless there are a variety of hypotheses that indicate that there are a host of factors that play important roles. Treatments for BKVAN include a reduction in immunosuppression, the use of antiviral therapy or the combination of both treatment options.

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Citations

Jan 24, 2019·Journal of Applied Oral Science : Revista FOB·Dmitry José de Santana SarmentoPaulo Henrique Braz-Silva
Mar 26, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ankur ShahJonathan J Hogan
Mar 28, 2019·Pediatric Transplantation·Hope BaroneTracy Funk
Mar 15, 2019·The Journal of Infectious Diseases·Susanna K TanBenjamin A Pinsky
Oct 30, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Alexander ClelandJuraj Petrik

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Methods Mentioned

BETA
biopsy
light microscopy
electron microscopy
biopsies
PCR

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